Treatment of Autoimmune Bullous Diseases During Pregnancy and Lactation: A Review Focusing on Pemphigus and Pemphigoid Gestationis

Giovanni Genovese, Federica Derlino, Emilio Berti, Angelo Valerio Marzano

Research output: Contribution to journalReview articlepeer-review

Abstract

Pregnancy may induce the onset or exacerbation of autoimmune bullous diseases such as pemphigus or pemphigoid gestationis. A shift toward T helper (Th) 2 immune response and the influence of hormonal changes have been evoked as possible triggering factors. Therapeutic management of this setting of patients may represent a challenge, mainly due to safety concerns of some immunosuppressive drugs during pregnancy and lactation. In this narrative review, we provided a comprehensive overview of the therapeutic management of autoimmune bullous diseases in pregnant and breastfeeding women, focusing on pemphigus and pemphigoid gestationis.

Original languageEnglish
Article number583354
JournalFrontiers in Pharmacology
Volume11
DOIs
Publication statusPublished - Oct 2 2020

Keywords

  • autoimmune bullous diseases
  • lactation
  • management
  • pemphigus
  • pregnancy
  • treatment

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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