Treatment of Cachexia: An Overview of Recent Developments

Stephan von Haehling, Stefan D. Anker

Research output: Contribution to journalArticlepeer-review

Abstract

Body wasting in the context of chronic illness is associated with reduced quality of life and impaired survival. Recent clinical trials have investigated different approaches to improve patients' skeletal muscle mass and strength, exercise capacity, and survival in the context of cachexia and body wasting, many of them in patients with cancer. The aim of this article was to summarize clinical trials published over the past 2years. Therapeutic approaches discussed include appetite stimulants, such as megestrol acetate, L-carnitine, or melatonin, anti-inflammatory drugs, such as thalidomide, pentoxyphylline, or a monoclonal antibody against interleukin-1α as well as ghrelin and the ghrelin agonist anamorelin; nutritional support, and anabolics, such as enobosarm and testosterone.

Original languageEnglish
Pages (from-to)866-872
Number of pages7
JournalJournal of the American Medical Directors Association
Volume15
Issue number12
DOIs
Publication statusPublished - Dec 1 2014

Keywords

  • Cachexia
  • Cancer
  • Therapy
  • Wasting

ASJC Scopus subject areas

  • Medicine(all)
  • Nursing(all)
  • Health Policy

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