Treatment of childhood post-irradiation sarcoma of bone in cancer survivors

G. Cefalo, A. Ferrari, J. D. Tesoro-Tess, M. C. Gianni, F. Fossati-Bellani, F. Lombardi, M. Massimino

Research output: Contribution to journalArticlepeer-review


Patients and Methods. This is a retrospective review of five children with post-irradiation bone sarcoma (PIS). Age at PIg onset ranged between 10 and 17 years (median 11). They were treated with a chemotherapy regimen, similar to that in use for primary osteogenic sarcoma, consisting of vincristine and high-dose methotrexate alternated with cisplatinum and ifosfamide, given for 12 months. Results. In all children chemotherapy induced a complete clinical remission. Four of them were alive in continuous complete remission at 1, 2, 4, and 12 years from the diagnosis of bone sarcoma. One girl recurred 3 years from PIS diagnosis and was salvaged by repeating the same chemotherapy program: she remained alive in second complete remission 8 years from relapse. Conclusions. In spite of an intensive treatment previously given for the primary tumor, this drug schedule proved to be feasible and short-term side effects were manageable. Chemotherapy alone, using an intensive regimen effective for primary osteogenic sarcoma, may be an adequate therapy for childhood post-irradiation sarcoma.

Original languageEnglish
Pages (from-to)568-572
Number of pages5
JournalMedical and Pediatric Oncology
Issue number6
Publication statusPublished - 1997


  • Chemotherapy
  • Childhood cancer survivors
  • Post-irradiation bone sarcoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pediatrics, Perinatology, and Child Health


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