Abstract
Patients and Methods. This is a retrospective review of five children with post-irradiation bone sarcoma (PIS). Age at PIg onset ranged between 10 and 17 years (median 11). They were treated with a chemotherapy regimen, similar to that in use for primary osteogenic sarcoma, consisting of vincristine and high-dose methotrexate alternated with cisplatinum and ifosfamide, given for 12 months. Results. In all children chemotherapy induced a complete clinical remission. Four of them were alive in continuous complete remission at 1, 2, 4, and 12 years from the diagnosis of bone sarcoma. One girl recurred 3 years from PIS diagnosis and was salvaged by repeating the same chemotherapy program: she remained alive in second complete remission 8 years from relapse. Conclusions. In spite of an intensive treatment previously given for the primary tumor, this drug schedule proved to be feasible and short-term side effects were manageable. Chemotherapy alone, using an intensive regimen effective for primary osteogenic sarcoma, may be an adequate therapy for childhood post-irradiation sarcoma.
| Original language | English |
|---|---|
| Pages (from-to) | 568-572 |
| Number of pages | 5 |
| Journal | Medical and Pediatric Oncology |
| Volume | 29 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 1997 |
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Keywords
- Chemotherapy
- Childhood cancer survivors
- Post-irradiation bone sarcoma
ASJC Scopus subject areas
- Cancer Research
- Oncology
- Pediatrics, Perinatology, and Child Health
Cite this
Treatment of childhood post-irradiation sarcoma of bone in cancer survivors. / Cefalo, G.; Ferrari, A.; Tesoro-Tess, J. D.; Gianni, M. C.; Fossati-Bellani, F.; Lombardi, F.; Massimino, M.
In: Medical and Pediatric Oncology, Vol. 29, No. 6, 1997, p. 568-572.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Treatment of childhood post-irradiation sarcoma of bone in cancer survivors
AU - Cefalo, G.
AU - Ferrari, A.
AU - Tesoro-Tess, J. D.
AU - Gianni, M. C.
AU - Fossati-Bellani, F.
AU - Lombardi, F.
AU - Massimino, M.
PY - 1997
Y1 - 1997
N2 - Patients and Methods. This is a retrospective review of five children with post-irradiation bone sarcoma (PIS). Age at PIg onset ranged between 10 and 17 years (median 11). They were treated with a chemotherapy regimen, similar to that in use for primary osteogenic sarcoma, consisting of vincristine and high-dose methotrexate alternated with cisplatinum and ifosfamide, given for 12 months. Results. In all children chemotherapy induced a complete clinical remission. Four of them were alive in continuous complete remission at 1, 2, 4, and 12 years from the diagnosis of bone sarcoma. One girl recurred 3 years from PIS diagnosis and was salvaged by repeating the same chemotherapy program: she remained alive in second complete remission 8 years from relapse. Conclusions. In spite of an intensive treatment previously given for the primary tumor, this drug schedule proved to be feasible and short-term side effects were manageable. Chemotherapy alone, using an intensive regimen effective for primary osteogenic sarcoma, may be an adequate therapy for childhood post-irradiation sarcoma.
AB - Patients and Methods. This is a retrospective review of five children with post-irradiation bone sarcoma (PIS). Age at PIg onset ranged between 10 and 17 years (median 11). They were treated with a chemotherapy regimen, similar to that in use for primary osteogenic sarcoma, consisting of vincristine and high-dose methotrexate alternated with cisplatinum and ifosfamide, given for 12 months. Results. In all children chemotherapy induced a complete clinical remission. Four of them were alive in continuous complete remission at 1, 2, 4, and 12 years from the diagnosis of bone sarcoma. One girl recurred 3 years from PIS diagnosis and was salvaged by repeating the same chemotherapy program: she remained alive in second complete remission 8 years from relapse. Conclusions. In spite of an intensive treatment previously given for the primary tumor, this drug schedule proved to be feasible and short-term side effects were manageable. Chemotherapy alone, using an intensive regimen effective for primary osteogenic sarcoma, may be an adequate therapy for childhood post-irradiation sarcoma.
KW - Chemotherapy
KW - Childhood cancer survivors
KW - Post-irradiation bone sarcoma
UR - http://www.scopus.com/inward/record.url?scp=0030882851&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030882851&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1096-911X(199712)29:6<568::AID-MPO9>3.0.CO;2-I
DO - 10.1002/(SICI)1096-911X(199712)29:6<568::AID-MPO9>3.0.CO;2-I
M3 - Article
C2 - 9324346
AN - SCOPUS:0030882851
VL - 29
SP - 568
EP - 572
JO - Pediatric Blood and Cancer
JF - Pediatric Blood and Cancer
SN - 1545-5009
IS - 6
ER -