Treatment of children with chronic hepatitis B with a combination of steroids and human lymphoblastoid interferon.

R. Giacchino, F. Facco, G. Giambartolomei, C. Navone, A. Timitilli, C. Cirillo, G. Barigione, A. Terragna

Research output: Contribution to journalArticlepeer-review

Abstract

The efficacy of human lymphoblastoid interferon (Wellferon) therapy was measured in 20 children with chronic hepatitis B with or without pretreatment with prednisolone. Patients were randomised to receive 0.6 mg/kg/day prednisolone for 3 weeks, then at 0.3 mg/kg for a fourth week or placebo. All patients then received interferon 5 MU/m2 i.m. for 12 weeks; daily for 5 days then three times a week for the remaining 11 weeks. Preliminary results show that 25% of children had a permanent loss of viral markers of replication. However, response to interferon varied widely between individuals and a prolonged follow-up is required in order to determine the influence of prednisolone pretreatment on the efficacy of interferon therapy.

Original languageEnglish
Pages (from-to)20-25
Number of pages6
JournalChemioterapia
Volume7 Suppl 3
Publication statusPublished - Dec 1988

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)

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