Seven patients with chronic immune thrombocytopenic purpura (ITP) were treated with intramuscular anti-D (anti-D IgG) five times, on an alternate-day basis, or until a platelet count of 100 x 10 9/l was achieved, and, subsequently, when necessary to maintain platelet counts above 50 x 10 9/l. Five patients responded to therapy, two of whom entered long-term remission. Although signs of haemolysis were present in all patients, anaemia was never a problem. No patient developed haematomas at the site of injection. We suggest that intramuscular anti-D represent a safe and relatively inexpensive alternative to intravenous gamma globulin (IVGG) for children with severe chronic ITP.
|Number of pages||3|
|Journal||British Journal of Haematology|
|Publication status||Published - 1994|
- Gamma globulins
- Idiopathic thrombocytopenia
- Immune thrombocytopenic purpura
ASJC Scopus subject areas