Treatment of chronic childhood immune thrombocytopenic purpura with intramuscular anti-D immunoglobulins

C. Borgna-Pignatti, L. Battisti, M. Zecca, F. Locatelli

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Seven patients with chronic immune thrombocytopenic purpura (ITP) were treated with intramuscular anti-D (anti-D IgG) five times, on an alternate-day basis, or until a platelet count of 100 x 10 9/l was achieved, and, subsequently, when necessary to maintain platelet counts above 50 x 10 9/l. Five patients responded to therapy, two of whom entered long-term remission. Although signs of haemolysis were present in all patients, anaemia was never a problem. No patient developed haematomas at the site of injection. We suggest that intramuscular anti-D represent a safe and relatively inexpensive alternative to intravenous gamma globulin (IVGG) for children with severe chronic ITP.

Original languageEnglish
Pages (from-to)618-620
Number of pages3
JournalBritish Journal of Haematology
Issue number3
Publication statusPublished - 1994



  • anti-D
  • anti-Rh
  • Gamma globulins
  • Idiopathic thrombocytopenia
  • Immune thrombocytopenic purpura

ASJC Scopus subject areas

  • Hematology

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