Treatment of chronic daily headache with medication overuse

L. Grazzi, F. Andrasik, D. D'Amico, S. Usai, A. Rigamonti, M. Leone, G. Bussone

Research output: Contribution to journalArticlepeer-review


Clinicians long have suspected that symptomatic medications taken by those with headache can cause rebound or drug-induced headaches if overused. This problem has been considered in the classification of headache disorders made by the International Headache Society. Patients who overuse medication must be withdrawn before their headache can be treated effectively. Sustained improvement following treatment for drug-induced headache can be difficult to achieve and at the moment there is no consensus on what approach may be more effective, in particular regarding outpatient or inpatient treatment withdrawal strategy. Clinical aspects and different therapeutic strategies for chronic daily headache patients with medication overuse are considered.

Original languageEnglish
JournalNeurological Sciences
Issue numberSUPPL. 2
Publication statusPublished - May 2003


  • Chronic daily headache
  • Medication overuse
  • Therapeutic strategies
  • Transformed migraine
  • Withdrawal

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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