Abstract
A case of disseminated granulomatous Geotrichum capitatum infection is reported. A young patient with blastic crisis of chronic myelogenous leukaemia developed septicaemia caused by G. capitatum in the post-chemotherapy aplastic phase. Subsequently, disseminated infection of the liver, spleen, pancreas and kidneys was observed. Treatment with high cumulative doses of a lipid formulation of amphotericin B (Amphocil®, 20.2 g in 11 weeks) and maintenance with itraconazole resolved clinical manifestations of G. capitatum granulomatons disseminated disease and controlled reactivation of the infection during the two subsequent courses of cytotoxic chemotherapy.
| Original language | English |
|---|---|
| Pages (from-to) | 377-384 |
| Number of pages | 8 |
| Journal | Mycoses |
| Volume | 38 |
| Issue number | 9-10 |
| Publication status | Published - 1995 |
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Keywords
- amphotericin B lipid formulation
- antimycotic chemotherapy
- disseminated infection
- Geotrichum capitatum
- granulomatous infection
- itraconazole
- leukaemia
ASJC Scopus subject areas
- Agricultural and Biological Sciences (miscellaneous)
- Microbiology
- Dermatology
Cite this
Treatment of chronic disseminated Geotrichum capitatum infection with high cumulative dose of colloidal amphotericin B and itraconazole in a leukaemia patient. / Cofrancesco, E.; Viviani, M. A.; Boschetti, C.; Tortorano, A. M.; Balzani, A.; Castagnone, D.
In: Mycoses, Vol. 38, No. 9-10, 1995, p. 377-384.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Treatment of chronic disseminated Geotrichum capitatum infection with high cumulative dose of colloidal amphotericin B and itraconazole in a leukaemia patient
AU - Cofrancesco, E.
AU - Viviani, M. A.
AU - Boschetti, C.
AU - Tortorano, A. M.
AU - Balzani, A.
AU - Castagnone, D.
PY - 1995
Y1 - 1995
N2 - A case of disseminated granulomatous Geotrichum capitatum infection is reported. A young patient with blastic crisis of chronic myelogenous leukaemia developed septicaemia caused by G. capitatum in the post-chemotherapy aplastic phase. Subsequently, disseminated infection of the liver, spleen, pancreas and kidneys was observed. Treatment with high cumulative doses of a lipid formulation of amphotericin B (Amphocil®, 20.2 g in 11 weeks) and maintenance with itraconazole resolved clinical manifestations of G. capitatum granulomatons disseminated disease and controlled reactivation of the infection during the two subsequent courses of cytotoxic chemotherapy.
AB - A case of disseminated granulomatous Geotrichum capitatum infection is reported. A young patient with blastic crisis of chronic myelogenous leukaemia developed septicaemia caused by G. capitatum in the post-chemotherapy aplastic phase. Subsequently, disseminated infection of the liver, spleen, pancreas and kidneys was observed. Treatment with high cumulative doses of a lipid formulation of amphotericin B (Amphocil®, 20.2 g in 11 weeks) and maintenance with itraconazole resolved clinical manifestations of G. capitatum granulomatons disseminated disease and controlled reactivation of the infection during the two subsequent courses of cytotoxic chemotherapy.
KW - amphotericin B lipid formulation
KW - antimycotic chemotherapy
KW - disseminated infection
KW - Geotrichum capitatum
KW - granulomatous infection
KW - itraconazole
KW - leukaemia
UR - http://www.scopus.com/inward/record.url?scp=0028838747&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028838747&partnerID=8YFLogxK
M3 - Article
C2 - 8569813
AN - SCOPUS:0028838747
VL - 38
SP - 377
EP - 384
JO - Mycoses
JF - Mycoses
SN - 0933-7407
IS - 9-10
ER -