Abstract
A case of disseminated granulomatous Geotrichum capitatum infection is reported. A young patient with blastic crisis of chronic myelogenous leukaemia developed septicaemia caused by G. capitatum in the post-chemotherapy aplastic phase. Subsequently, disseminated infection of the liver, spleen, pancreas and kidneys was observed. Treatment with high cumulative doses of a lipid formulation of amphotericin B (Amphocil®, 20.2 g in 11 weeks) and maintenance with itraconazole resolved clinical manifestations of G. capitatum granulomatons disseminated disease and controlled reactivation of the infection during the two subsequent courses of cytotoxic chemotherapy.
| Original language | English |
|---|---|
| Pages (from-to) | 377-384 |
| Number of pages | 8 |
| Journal | Mycoses |
| Volume | 38 |
| Issue number | 9-10 |
| Publication status | Published - 1995 |
Keywords
- amphotericin B lipid formulation
- antimycotic chemotherapy
- disseminated infection
- Geotrichum capitatum
- granulomatous infection
- itraconazole
- leukaemia
ASJC Scopus subject areas
- Agricultural and Biological Sciences (miscellaneous)
- Microbiology
- Dermatology
Fingerprint Dive into the research topics of 'Treatment of chronic disseminated Geotrichum capitatum infection with high cumulative dose of colloidal amphotericin B and itraconazole in a leukaemia patient'. Together they form a unique fingerprint.
Cite this
Cofrancesco, E., Viviani, M. A., Boschetti, C., Tortorano, A. M., Balzani, A., & Castagnone, D. (1995). Treatment of chronic disseminated Geotrichum capitatum infection with high cumulative dose of colloidal amphotericin B and itraconazole in a leukaemia patient. Mycoses, 38(9-10), 377-384.