Treatment of chronic disseminated Geotrichum capitatum infection with high cumulative dose of colloidal amphotericin B and itraconazole in a leukaemia patient

E. Cofrancesco, M. A. Viviani, C. Boschetti, A. M. Tortorano, A. Balzani, D. Castagnone

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

A case of disseminated granulomatous Geotrichum capitatum infection is reported. A young patient with blastic crisis of chronic myelogenous leukaemia developed septicaemia caused by G. capitatum in the post-chemotherapy aplastic phase. Subsequently, disseminated infection of the liver, spleen, pancreas and kidneys was observed. Treatment with high cumulative doses of a lipid formulation of amphotericin B (Amphocil®, 20.2 g in 11 weeks) and maintenance with itraconazole resolved clinical manifestations of G. capitatum granulomatons disseminated disease and controlled reactivation of the infection during the two subsequent courses of cytotoxic chemotherapy.

Original languageEnglish
Pages (from-to)377-384
Number of pages8
JournalMycoses
Volume38
Issue number9-10
Publication statusPublished - 1995

Fingerprint

Geotrichum
Itraconazole
itraconazole
amphotericin B
Amphotericin B
leukemia
Leukemia
drug therapy
dosage
Infection
infection
Drug Therapy
septicemia
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
pancreas
Pancreas
Sepsis
spleen
Therapeutics
Spleen

Keywords

  • amphotericin B lipid formulation
  • antimycotic chemotherapy
  • disseminated infection
  • Geotrichum capitatum
  • granulomatous infection
  • itraconazole
  • leukaemia

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Microbiology
  • Dermatology

Cite this

Treatment of chronic disseminated Geotrichum capitatum infection with high cumulative dose of colloidal amphotericin B and itraconazole in a leukaemia patient. / Cofrancesco, E.; Viviani, M. A.; Boschetti, C.; Tortorano, A. M.; Balzani, A.; Castagnone, D.

In: Mycoses, Vol. 38, No. 9-10, 1995, p. 377-384.

Research output: Contribution to journalArticle

Cofrancesco, E. ; Viviani, M. A. ; Boschetti, C. ; Tortorano, A. M. ; Balzani, A. ; Castagnone, D. / Treatment of chronic disseminated Geotrichum capitatum infection with high cumulative dose of colloidal amphotericin B and itraconazole in a leukaemia patient. In: Mycoses. 1995 ; Vol. 38, No. 9-10. pp. 377-384.
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