Treatment of clinical signs and EEG patterns in patients with "organic brain syndrome". Effects of citidin-diphosphocholine, citicholine (Brassel* * BRASSEL - Schiapparelli Farmaceutici SpA, Turin, Italy.)

The effects of acute and chronic administration of citicholine (Brassel) on the EEG spectral analysis and clinical features of patients with organic brain syndrome have been evaluated in patients with "organic brain syndrome.". The chronic citicholine treatment induced EEG modification, mainly, a significant increase in the power of the alpha frequency and a significant reduction of the delta power. An evident improvement was obtained in the behavioural rating scales and in the quantitative tests of the attentive concentration levels. After acute administration there was a significant reduction of the delta frequencies, possibly induced by an improvement of vigilance.