Treatment of cutaneous angiosarcoma of the face

Efficacy of combined chemotherapy and radiotherapy

Vincenzo Ravo, Sara Falivene, Annarosaria De Chiara, Giampaolo De Palma, Antonio Pizzolorusso, Rossella Di Franco, Paolo Muto, Gaetano Apice

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Introduction. Cutaneous angiosarcoma (AS) is a rare form of soft tissue sarcoma. It is aggressive and has a poor prognosis. The aim of our report is to show that with combined chemotherapy and radiotherapy it is possible to obtain good results in terms of local control, complete response, and aesthetic outcome. Case report.We present the case of a 60-year-old man affected by AS covering the entire surface of the nose. Surgery, although indicated, was excluded because it was considered mutilating and would give a poor cosmetic result. The patient was treated with chemotherapy consisting of paclitaxel 80 mg/m2 for 6 cycles followed by radiotherapy at a dose of 50 Gy. Then 3 additional cycles of chemotherapy were administered according to the same scheme. A complete response was obtained. At 40 months after treatment, the patient did not show any signs of late toxicity, all lesions had disappeared, and all laboratory tests were negative. Conclusions. Our experience shows that concomitant chemoradiotherapy can be delivered safely and can be tolerated with low toxicity and good results in terms of local control and complete response. We obtained an excellent aesthetic result with improvement of the patient's quality of life.

Original languageEnglish
JournalTumori
Volume99
Issue number5
DOIs
Publication statusPublished - Sep 2013

Fingerprint

Hemangiosarcoma
Radiotherapy
Esthetics
Drug Therapy
Skin
Chemoradiotherapy
Paclitaxel
Nose
Cosmetics
Sarcoma
Therapeutics
Quality of Life

Keywords

  • Chemotherapy
  • Cutaneous angiosarcoma
  • Radiotherapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Treatment of cutaneous angiosarcoma of the face : Efficacy of combined chemotherapy and radiotherapy. / Ravo, Vincenzo; Falivene, Sara; De Chiara, Annarosaria; De Palma, Giampaolo; Pizzolorusso, Antonio; Di Franco, Rossella; Muto, Paolo; Apice, Gaetano.

In: Tumori, Vol. 99, No. 5, 09.2013.

Research output: Contribution to journalArticle

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