Treatment of denervated muscle by gangliosides

M. R. Caccia, G. Meola, C. Cerri, L. Frattola, G. Scarlato, F. Aporti

Research output: Contribution to journalArticle

Abstract

Short‐duration cooling of the nerve to the extensor digitorum longus muscle of the rat in vivo induced partially reversible denervation of the muscle and atrophy in the type 2 muscle fibers. Increases in cyclic adenosine monophosphate, cyclic guanosine monophosphate phosphodiesterase, adenylate cyclase, and guanlate cyclase were observed in the denervated muscle. Treatment with gangliosides of the bovine brain cortex seemed to improve the excitability of the surviving motor units and to encourage recovery of neuromuscular trophic control, but it did not affect the nerve conduction velocity or the contractile properties of the denervated muscle.

Original languageEnglish
Pages (from-to)382-389
Number of pages8
JournalMuscle and Nerve
Volume2
Issue number5
DOIs
Publication statusPublished - 1979

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

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  • Cite this

    Caccia, M. R., Meola, G., Cerri, C., Frattola, L., Scarlato, G., & Aporti, F. (1979). Treatment of denervated muscle by gangliosides. Muscle and Nerve, 2(5), 382-389. https://doi.org/10.1002/mus.880020510