Treatment of epidermolysis bullosa acquisita with cyclosporine and prednisone

S. Veraldi, M. Bocor, A. Brusasco, R. Caputo

Research output: Contribution to journalArticlepeer-review

Abstract

A case of epidermolysis bullosa acquisita in a 58-year-old woman is described. The diagnosis was made on the basis of the clinical picture as well as the histopathological, immunopathological and ultrastructural findings. The patient was treated for over 4 years with corticosteroids, azathioprine, etretinate and dapsone; these drugs produced only partial remissions of short duration. Furthermore, the patient developed many severe side-effects induced by corticosteroids. For these reasons, treatment was started with cyclosporine (5 mg/kg per day) and prednisone (5 mg/day), resulting in complete remission of cutaneous lesions within 3 months. The dosage was subsequently reduced by 0.5 mg/kg per day every 6 months. After 3 years and 6 months the patient was still under treatment with cyclosporine (3 mg/kg per day) and prednisone (5 mg/day). No relevant side-effects induced by cyclosporine had been seen. This case suggests that cyclosporine, combined with prednisone, can be efficacious in the treatment of epidermolysis bullosa acquisita even at low dosages.

Original languageEnglish
Pages (from-to)85-87
Number of pages3
JournalJournal of Dermatological Treatment
Volume4
Issue number2
DOIs
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Dermatology

Fingerprint

Dive into the research topics of 'Treatment of epidermolysis bullosa acquisita with cyclosporine and prednisone'. Together they form a unique fingerprint.

Cite this