TERAPIA DEL SARCOMA DI EWING NON METASTATICO (PELVI ESCLUSA). RISULTATI OTTENUTI IN 48 CASI ASSOCIANDO ALLA TERAPIA LOCALE (RADIANTE E/O CHIRURGICA) UNA CHEMIOTERAPIA ADIUVANTE CON VINCRISTINA, ADRIAMICINA, DACTINOMICINA E CICLOFOSFAMIDE

Translated title of the contribution: Treatment of extrapelvic non metastatic Ewing's sarcoma: Results obtained in 48 cases treated by a combination of local radiation and/or surgery and adjuvant chemotherapy with vincristine, adriamycin, dactinomycin and cyclophosphamide

A. Sudanese, M. Avella, A. Toni, S. Boriani, N. Baldini, M. Monesi, A. Battistini, A. Mancini, M. Campanacci

Research output: Contribution to journalArticle

Abstract

Combined therapy was used on a consecutive series of 48 patients with extrapelvic Ewing's sarcoma at the Rizzoli Orthopaedic Institute. The adjuvant chemotherapy protocol (VCR, ADM, D-ACT, EDX) was identical in all patients whereas local treatment consisted of amputation, resection and radiation treatment or radiation alone. At a mean follow-up of 58 months (39-78) 30 patients (60%) were free of the disease. This is a significantly higher percentage than that obtained in the same period with adjuvant chemotherapy using only 3 drugs (VCR, ADM, EDX). As far as the type of local treatment is concerned, the percentage of local recurrences and metastases was lower when the primary lesion was treated with surgery or surgery combined with radiotherapy, rather than radiotherapy treatment alone. These suggest that if associated with radiation treatment and chemotherapy, surgery can play an important role that should be considered in the treatment of extrapelvic Ewing's sarcoma.

Original languageItalian
Pages (from-to)473-482
Number of pages10
JournalMinerva Medica
Volume78
Issue number7
Publication statusPublished - 1987

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ASJC Scopus subject areas

  • Medicine(all)

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