Treatment of Helicobacter pylori and Chlamydia pneumoniae infections decreases fibrinogen plasma level in patients with ischemic heart disease

Giuseppe Torgano, Roberto Cosentini, Clara Mandelli, Rodolfo Perondi, Francesco Blasi, Giovanni Bertinieri, Tu Van Tien, Giuliana Ceriani, Paolo Tarsia, Cristina Arosio, Maria Luisa Ranzi

Research output: Contribution to journalArticle

Abstract

Background - Chronic Chlamydia pneumoniae and Helicobacter pylori infections could be a risk factor for ischemic heart disease (IHD), possibly by increasing fibrinogen levels. The aim of our study was to evaluate changes in fibrinogen level in patients with IHD and H pylori and/or C pneumoniae positivity randomly assigned to antibiotic treatment. Methods and Results - Eighty-four patients with chronic IHD, H pylori and/or C pneumoniae antibodies, and normal acute-phase reactants were randomly assigned to treatment or no treatment. Treatment consisted of omeprazole, clarithromycin, and tinidazole in H pylori-positive patients and clarithromycin alone in C pneumoniae-positive patients. The effect of treatment and other baseline variables on fibrinogen levels, determined at 6 months, was evaluated by multivariate analysis. Treatment significantly reduced fibrinogen level at 6 months in the overall study population and in the groups of patients divided according to H pylori or C pneumoniae positivity. In the 43 treated patients, mean (±SD) basal fibrinogen was 3.65±0.58 g/L, and mean final fibrinogen was 3.09±0.52 g/dL (P

Original languageEnglish
Pages (from-to)1555-1559
Number of pages5
JournalCirculation
Volume99
Issue number12
Publication statusPublished - Mar 30 1999

Keywords

  • C pneumoniae
  • Fibrinogen
  • H pylori
  • Ischemia

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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    Torgano, G., Cosentini, R., Mandelli, C., Perondi, R., Blasi, F., Bertinieri, G., Tien, T. V., Ceriani, G., Tarsia, P., Arosio, C., & Ranzi, M. L. (1999). Treatment of Helicobacter pylori and Chlamydia pneumoniae infections decreases fibrinogen plasma level in patients with ischemic heart disease. Circulation, 99(12), 1555-1559.