Abstract
The recently approved interferon-free DAA (direct antiviral agents) regimens have shown not only to be effective in terms of sustained virological response (SVR) rates (> 90%) but also well tolerated in most hepatitis C virus (HCV) infected patients. Nevertheless HCV genotypes are different and only a small percentage of trials consider genotype 4 (GT4), which was associated with lower rates of SVR compared with other genotypes before the arrival of the DAA's. In this review, we discuss the efficacy of DAA therapy in GT4 HCV infection with specific reference to more recent studies, including those conducted in a 'field-practice' scenario. Overall, DAA-based regimens appear more effective also in the poorly-explored setting of patients with HCV GT4 infection. Despite an overall limited number of patients was evaluated, favorable results are being derived from studies on ombitasvir/paritaprevir/ritonavir, sofosbuvir and velpatasvir, whether or not in association with voxilaprevir, and with the new combined therapy glecaprevir + pibentasvir.
| Original language | English |
|---|---|
| Number of pages | 1 |
| Journal | Virology Journal |
| Volume | 15 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Nov 22 2018 |
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ASJC Scopus subject areas
- Virology
- Infectious Diseases
Cite this
Treatment of hepatitis C virus genotype 4 in the DAA era. / Di Biagio, Antonio; Taramasso, Lucia; Cenderello, Giovanni.
In: Virology Journal, Vol. 15, No. 1, 22.11.2018.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Treatment of hepatitis C virus genotype 4 in the DAA era
AU - Di Biagio, Antonio
AU - Taramasso, Lucia
AU - Cenderello, Giovanni
PY - 2018/11/22
Y1 - 2018/11/22
N2 - The recently approved interferon-free DAA (direct antiviral agents) regimens have shown not only to be effective in terms of sustained virological response (SVR) rates (> 90%) but also well tolerated in most hepatitis C virus (HCV) infected patients. Nevertheless HCV genotypes are different and only a small percentage of trials consider genotype 4 (GT4), which was associated with lower rates of SVR compared with other genotypes before the arrival of the DAA's. In this review, we discuss the efficacy of DAA therapy in GT4 HCV infection with specific reference to more recent studies, including those conducted in a 'field-practice' scenario. Overall, DAA-based regimens appear more effective also in the poorly-explored setting of patients with HCV GT4 infection. Despite an overall limited number of patients was evaluated, favorable results are being derived from studies on ombitasvir/paritaprevir/ritonavir, sofosbuvir and velpatasvir, whether or not in association with voxilaprevir, and with the new combined therapy glecaprevir + pibentasvir.
AB - The recently approved interferon-free DAA (direct antiviral agents) regimens have shown not only to be effective in terms of sustained virological response (SVR) rates (> 90%) but also well tolerated in most hepatitis C virus (HCV) infected patients. Nevertheless HCV genotypes are different and only a small percentage of trials consider genotype 4 (GT4), which was associated with lower rates of SVR compared with other genotypes before the arrival of the DAA's. In this review, we discuss the efficacy of DAA therapy in GT4 HCV infection with specific reference to more recent studies, including those conducted in a 'field-practice' scenario. Overall, DAA-based regimens appear more effective also in the poorly-explored setting of patients with HCV GT4 infection. Despite an overall limited number of patients was evaluated, favorable results are being derived from studies on ombitasvir/paritaprevir/ritonavir, sofosbuvir and velpatasvir, whether or not in association with voxilaprevir, and with the new combined therapy glecaprevir + pibentasvir.
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UR - http://www.scopus.com/inward/citedby.url?scp=85057106126&partnerID=8YFLogxK
U2 - 10.1186/s12985-018-1094-4
DO - 10.1186/s12985-018-1094-4
M3 - Review article
C2 - 30466446
AN - SCOPUS:85057106126
VL - 15
JO - Virology Journal
JF - Virology Journal
SN - 1743-422X
IS - 1
ER -