Treatment of hepatitis C virus genotype 4 in the DAA era

Antonio Di Biagio, Lucia Taramasso, Giovanni Cenderello

Research output: Contribution to journalReview articlepeer-review

Abstract

The recently approved interferon-free DAA (direct antiviral agents) regimens have shown not only to be effective in terms of sustained virological response (SVR) rates (> 90%) but also well tolerated in most hepatitis C virus (HCV) infected patients. Nevertheless HCV genotypes are different and only a small percentage of trials consider genotype 4 (GT4), which was associated with lower rates of SVR compared with other genotypes before the arrival of the DAA's. In this review, we discuss the efficacy of DAA therapy in GT4 HCV infection with specific reference to more recent studies, including those conducted in a 'field-practice' scenario. Overall, DAA-based regimens appear more effective also in the poorly-explored setting of patients with HCV GT4 infection. Despite an overall limited number of patients was evaluated, favorable results are being derived from studies on ombitasvir/paritaprevir/ritonavir, sofosbuvir and velpatasvir, whether or not in association with voxilaprevir, and with the new combined therapy glecaprevir + pibentasvir.

Original languageEnglish
Number of pages1
JournalVirology Journal
Volume15
Issue number1
DOIs
Publication statusPublished - Nov 22 2018

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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