TRATTAMENTO DELL'EPATOCARCINOMA PRIMITIVO MEDIANTE CHEMIOEMBOLIZZAZIONE E ALCOLIZZAZIONE. ESPERIENZA PERSONALE

F. Florio; M. Nardella; S. Balzano; A. Andriulli; E. Caturelli; D. Siena; M. Bisceglia; S. Fusilli; M. G. Scarale; M. Cammisa

TRATTAMENTO DELL'EPATOCARCINOMA PRIMITIVO MEDIANTE CHEMIOEMBOLIZZAZIONE E ALCOLIZZAZIONE. ESPERIENZA PERSONALE

Translated title of the contribution: Treatment of hepatocellular carcinoma by transcatheter chemoembolization or percutaneous ethanol injection. Our personal experience

F. Florio, M. Nardella, S. Balzano, A. Andriulli, E. Caturelli, D. Siena, M. Bisceglia, S. Fusilli, M. G. Scarale, M. Cammisa

IRCCS Casa Sollievo della Sofferenza

Research output: Contribution to journal › Article › peer-review

Abstract

The comparative efficacy of transcatheter arterial chemoembolization and percutaneous ethanol injection (PEI) in the treatment of hepatocellular carcinoma (HCC) was investigated in a series of 243 consecutive patients: 146 of them were submitted to 1-6 chemoembolization sessions at 1 and 3 months' intervals and 30 to PEI; the remaining 67 patients refused any treatment. The follow-up ranged 3 to 36 months. Survival rates were statistically analyzed with the life table analysis. Patients' survival was affected by the number of nodules and by Child's and Okuda's classes; no relationship was found between survival rates and histologic grade or nodule vascular feeding. In case of single lesions, chemoembolization was more effective than PEI in Okuda's class I. In case of multifocal HCC, chemoembolization was better than no treatment in Okuda's class I and Child's class A. In conclusion, we suggest chemoembolization as the treatment of choice in Child A or Okuda I patients with multifocal HCCs, while its use seems of little help in Child B-C or Okuda II-III patients. In case of unifocal HCC, PEI or surgical resection should be combined with chemoembolization.

Translated title of the contribution	Treatment of hepatocellular carcinoma by transcatheter chemoembolization or percutaneous ethanol injection. Our personal experience
Original language	Italian
Pages (from-to)	821-826
Number of pages	6
Journal	Radiologia Medica
Volume	88
Issue number	6
Publication status	Published - 1994

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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TRATTAMENTO DELL'EPATOCARCINOMA PRIMITIVO MEDIANTE CHEMIOEMBOLIZZAZIONE E ALCOLIZZAZIONE. ESPERIENZA PERSONALE. / Florio, F.; Nardella, M.; Balzano, S.; Andriulli, A.; Caturelli, E.; Siena, D.; Bisceglia, M.; Fusilli, S.; Scarale, M. G.; Cammisa, M.

In: Radiologia Medica, Vol. 88, No. 6, 1994, p. 821-826.

Research output: Contribution to journal › Article › peer-review

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abstract = "The comparative efficacy of transcatheter arterial chemoembolization and percutaneous ethanol injection (PEI) in the treatment of hepatocellular carcinoma (HCC) was investigated in a series of 243 consecutive patients: 146 of them were submitted to 1-6 chemoembolization sessions at 1 and 3 months' intervals and 30 to PEI; the remaining 67 patients refused any treatment. The follow-up ranged 3 to 36 months. Survival rates were statistically analyzed with the life table analysis. Patients' survival was affected by the number of nodules and by Child's and Okuda's classes; no relationship was found between survival rates and histologic grade or nodule vascular feeding. In case of single lesions, chemoembolization was more effective than PEI in Okuda's class I. In case of multifocal HCC, chemoembolization was better than no treatment in Okuda's class I and Child's class A. In conclusion, we suggest chemoembolization as the treatment of choice in Child A or Okuda I patients with multifocal HCCs, while its use seems of little help in Child B-C or Okuda II-III patients. In case of unifocal HCC, PEI or surgical resection should be combined with chemoembolization.",

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author = "F. Florio and M. Nardella and S. Balzano and A. Andriulli and E. Caturelli and D. Siena and M. Bisceglia and S. Fusilli and Scarale, {M. G.} and M. Cammisa",

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AU - Florio, F.

AU - Nardella, M.

AU - Balzano, S.

AU - Andriulli, A.

AU - Caturelli, E.

AU - Siena, D.

AU - Bisceglia, M.

AU - Fusilli, S.

AU - Scarale, M. G.

AU - Cammisa, M.

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AB - The comparative efficacy of transcatheter arterial chemoembolization and percutaneous ethanol injection (PEI) in the treatment of hepatocellular carcinoma (HCC) was investigated in a series of 243 consecutive patients: 146 of them were submitted to 1-6 chemoembolization sessions at 1 and 3 months' intervals and 30 to PEI; the remaining 67 patients refused any treatment. The follow-up ranged 3 to 36 months. Survival rates were statistically analyzed with the life table analysis. Patients' survival was affected by the number of nodules and by Child's and Okuda's classes; no relationship was found between survival rates and histologic grade or nodule vascular feeding. In case of single lesions, chemoembolization was more effective than PEI in Okuda's class I. In case of multifocal HCC, chemoembolization was better than no treatment in Okuda's class I and Child's class A. In conclusion, we suggest chemoembolization as the treatment of choice in Child A or Okuda I patients with multifocal HCCs, while its use seems of little help in Child B-C or Okuda II-III patients. In case of unifocal HCC, PEI or surgical resection should be combined with chemoembolization.

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KW - HCC, PEI

KW - HCC, prognosis and therapy

KW - liver, HCC

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TRATTAMENTO DELL'EPATOCARCINOMA PRIMITIVO MEDIANTE CHEMIOEMBOLIZZAZIONE E ALCOLIZZAZIONE. ESPERIENZA PERSONALE

Abstract

ASJC Scopus subject areas

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