Treatment of hereditary angioedema

Bianca Marasini, M. Cicardi, G. C. Martignoni, A. Agostoni

Research output: Contribution to journalArticle

Abstract

The purpose of this study was to report the results of different treatments in 20 patients with hereditary angioedema. Effectiveness of tranexamic acid in preventing swellings was evaluated in 15 patients: in all but 3 subjects tranexamic acid was effective without serious side effects. 15 severe attacks of edema were managed with intravenous infusions of either kallikrein inhibitor (8 cases) or concentrate of C 1 esterase inhibitor (7 cases). In only 1 case was the kallikrein inhibitor unsuccessful. C 1 esterase inhibitor concentrate proved highly effective in the treatment of acute attacks (the result was lacking in one patient because of too low dosage of the drug). No side effects were observed with both treatments, but improvement was more rapidly achieved with infusion of C 1 esterase inhibitor. The serum levels of C 4 and C 1 esterase inhibitor and the activity of C 1 esterase inhibitor before and after long-term prophylaxis and acute attacks treatment were investigated.

Original languageEnglish
Pages (from-to)819-823
Number of pages5
JournalKlinische Wochenschrift
Volume56
Issue number16
DOIs
Publication statusPublished - Aug 1978

Keywords

  • C 1 esterase inhibitor
  • Hereditary angioedema
  • Kallikrein inhibitor
  • Tranexamic acid

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Marasini, B., Cicardi, M., Martignoni, G. C., & Agostoni, A. (1978). Treatment of hereditary angioedema. Klinische Wochenschrift, 56(16), 819-823. https://doi.org/10.1007/BF01489716