Treatment of human immunodeficiency virus infection with hydroxyurea: Virologic and clinical evaluation

Mauro Giacca, Stefania Zanussi, Manola Comar, Cecilia Simonelli, Emanuela Vaccher, Paolo De Paoli, Umberto Tirelli

Research output: Contribution to journalArticle

Abstract

To assess the efficacy of the therapeutic use of inhibitors of ribonucleotide reductase for the treatment of human immunodeficiency virus (HIV) type 1 infection, 7 consecutive patients were enrolled in a clinical trial involving monotherapy with hydroxyurea for 8-19 weeks. During therapy, patients were evaluated for clinical status and immunologic, hematologic, and quantitative virologic parameters, including determinations of viremia and the number of provirus-containing cells by competitive polymerase chain reaction. In all patients, these parameters were not modified during the course of therapy. The number of CD4 cells remained generally unchanged or showed a tendency to further decline. No sign of improvement in HIV disease was detected in any patient. These observations indicate that monotherapy with hydroxyurea does not provide therapeutic benefit to HIV-1-infected patients.

Original languageEnglish
Pages (from-to)204-209
Number of pages6
JournalJournal of Infectious Diseases
Volume174
Issue number1
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

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