Treatment of hyperhomocysteinemia in pediatric heart transplant recipients

Francesco Parisi, Hélène Danesi, Vincenzo Di Ciommo, Francesca Fina, Germana Giannone, Franco Colistro, Roberto M. Di Donato, Glauco Catena

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Graft coronary artery vasculopathy is the main cause of late morbidity and mortality in pediatric cardiac allograft recipients. Growing evidence suggests that elevated plasma homocysteine levels are associated with cardiac allograft vasculopathy following heart transplantation. The purpose of this study was to evaluate the effect of vitamin supplementation as a potential strategy for reducing homocysteine levels in pediatric heart transplant recipients and examine creatinine levels as potential determinants of plasma homocysteine concentration after transplantation. Methods: We studied 27 pediatric heart transplant patients with homocysteine levels higher than normal. All children received vitamin supplementation (vitamin B12, vitamin E, vitamin A and folic acid). During treatment, levels of homocysteine, vitamins and creatinine were evaluated after 3, 6, 9 and 12 months. Results: We observed a significant homocysteine concentration decrease after treatment at every determination, whereas no significant change occurred for creatinine. Vitamin B12 serum level increased markedly, whereas folic acid, vitamin E and vitamin A serum levels showed only minor increases. Conclusions: We observed a significant increase of mean levels of vitamin B12 and a moderate increase in the other 3 vitamins. We also observed a significant reduction in homocysteine levels, which returned to normal levels for age. In our patients, there was a correlation, before and after treatment, between homocysteine and creatinine levels, but there was no a direct correlation between creatinine serum levels and homocysteine reduction. We conclude that vitamin supplementation reduces and may normalize homocysteine serum level after pediatric heart transplantation.

Original languageEnglish
Pages (from-to)778-783
Number of pages6
JournalJournal of Heart and Lung Transplantation
Volume22
Issue number7
DOIs
Publication statusPublished - Jul 1 2003

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Hyperhomocysteinemia
Homocysteine
Pediatrics
Vitamins
Creatinine
Vitamin B 12
Therapeutics
Heart Transplantation
Serum
Folic Acid
Allografts
Transplant Recipients
Transplants
Tretinoin
Vitamin E
Coronary Vessels
Transplantation
Morbidity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Transplantation

Cite this

Treatment of hyperhomocysteinemia in pediatric heart transplant recipients. / Parisi, Francesco; Danesi, Hélène; Di Ciommo, Vincenzo; Fina, Francesca; Giannone, Germana; Colistro, Franco; Di Donato, Roberto M.; Catena, Glauco.

In: Journal of Heart and Lung Transplantation, Vol. 22, No. 7, 01.07.2003, p. 778-783.

Research output: Contribution to journalArticle

Parisi, F, Danesi, H, Di Ciommo, V, Fina, F, Giannone, G, Colistro, F, Di Donato, RM & Catena, G 2003, 'Treatment of hyperhomocysteinemia in pediatric heart transplant recipients', Journal of Heart and Lung Transplantation, vol. 22, no. 7, pp. 778-783. https://doi.org/10.1016/S1053-2498(02)00666-6
Parisi, Francesco ; Danesi, Hélène ; Di Ciommo, Vincenzo ; Fina, Francesca ; Giannone, Germana ; Colistro, Franco ; Di Donato, Roberto M. ; Catena, Glauco. / Treatment of hyperhomocysteinemia in pediatric heart transplant recipients. In: Journal of Heart and Lung Transplantation. 2003 ; Vol. 22, No. 7. pp. 778-783.
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AU - Di Donato, Roberto M.

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