Treatment of hypertension: General aspects

G. Mancia, M. L. Stella, M. Pozzi, G. Grassi

Research output: Contribution to journalArticlepeer-review


Although hypertension is often a symptomless condition, evidence exists that it is a major risk factor for cardiovascular disease. There is also evidence from a large number of intervention trials that reduction of elevated blood pressure by antihypertensive drugs is accompanied by a decreased risk for cardiovascular morbidity and mortality. This decrease is due to protection against stroke, congestive heart failure and, to a lesser extent, coronary artery disease. This article reviews the approaches to treatment of hypertension. The step-care approach is discussed in detail, from its birth to its latest evolution in the WHO/ISH and JNC guidelines. Substitution monotherapy and other therapeutic strategies are also examined for their pros and cons vs. step-care therapy.

Original languageEnglish
JournalJournal of Cardiovascular Pharmacology
Issue numberSUPPL. 4
Publication statusPublished - 1996


  • Antihypertensive treatment
  • Cardiovascular risk factors
  • Clinical trials
  • Guidelines

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine


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