Treatment of hypertension: General aspects

G. Mancia, M. L. Stella, M. Pozzi, G. Grassi

Research output: Contribution to journalArticle


Although hypertension is often a symptomless condition, evidence exists that it is a major risk factor for cardiovascular disease. There is also evidence from a large number of intervention trials that reduction of elevated blood pressure by antihypertensive drugs is accompanied by a decreased risk for cardiovascular morbidity and mortality. This decrease is due to protection against stroke, congestive heart failure and, to a lesser extent, coronary artery disease. This article reviews the approaches to treatment of hypertension. The step-care approach is discussed in detail, from its birth to its latest evolution in the WHO/ISH and JNC guidelines. Substitution monotherapy and other therapeutic strategies are also examined for their pros and cons vs. step-care therapy.

Original languageEnglish
JournalJournal of Cardiovascular Pharmacology
Issue numberSUPPL. 4
Publication statusPublished - 1996


  • Antihypertensive treatment
  • Cardiovascular risk factors
  • Clinical trials
  • Guidelines

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Treatment of hypertension: General aspects'. Together they form a unique fingerprint.

  • Cite this

    Mancia, G., Stella, M. L., Pozzi, M., & Grassi, G. (1996). Treatment of hypertension: General aspects. Journal of Cardiovascular Pharmacology, 28(SUPPL. 4).