Forty-two elderly patients with systolic/diastolic or isolated systolic hypertension took part in the present clinical pilot trial designed to compare the antihypertensive actions of and tolerance to dihydroergotoxine mesilate (DHT) and nifedipine (Nif). DHT was found to have a good antihypertensive action, similar to that of Nif, on both supine and standing blood pressure (BP), after a 7-weeks treatment period. No appreciable modifications of mean pulse rate (PR) were found after either treatment. The mean final DHT dose was 6.6 mg/day and about half the patients required only 4.5 mg/day, o.d. The mean final Nif dose was 21.9% mg/day, mostly divided into two daily administrations. The frequency of side effects was lower in the group of patients taking DHT (10%) than in the Nif group (62%), but no symptoms referable to hypotension were observed. The results of this pilot trial confirm the good antihypertensive action of DHT in elderly people, similar to that of Nif, but perhaps with some advantage in terms of side effects.
|Number of pages||9|
|Journal||Current Therapeutic Research|
|Publication status||Published - 1983|
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