Treatment of hyperthyroidism due to inappropriate secretion of thyrotropin with the somatostatin analog SMS 201-995

P. Beck-Peccoz, S. Mariotti, P. J. Guillausseau, G. Medri, G. Piscitelli, A. Bertoli, A. Barbarino, M. Rondena, P. Chanson, A. Pinchera, G. Faglia

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Abstract

The management of hyperthyroidism due to inappropriate secretion of TSH (IST) includes agents that selectively suppress TSH hypersecretion both in patients with TSH-secreting tumor [neoplastic IST (nIST)] in whom pituitary surgery was unsuccessful and in those with selective pituitary resistance to thyroid hormone action [nonneoplastic IST (nnIST)]. Among such agents, somatostatin administration has proven to be effective in blocking TSH hypersecretion, but its short plasma half-life prevented its use in long term therapeutic trials. The recent availability of a potent and long-acting analog of somatostatin (SMS 201-995, Sandostatin) prompted us to study its effects on serum TSH, α-subunit, and free thyroid hormone (FT 4 and FT 3) concentrations in five patients with nIST and three patients with nnIST. During short term SMS 201-995 administration (100 μg, sc, three times daily for 5 days) both serum TSH and α-subunit levels decreased in all patients with nIST (mean decrement,s -86% and -85%, respectively), with concomitant normalization of serum FT 4 and FT 3 concentrations. In the three patients with nnIST, this treatment lowered serum TSH levels less well (mean decrement, -47%), although serum FT 4 and FT 3 levels normalized in one patient. Chronic SMS 201-995 (100 μg, sc, every 12 h for 1-7 months) treatment in four hyperthyroid patients (two with nIST and two with nnIST) resulted in a steady euthyroid state in both patients with nIST, with restoration of normal visual fields in one patient. In contrast, in both patients with nnIST, escape occurred after 2 weeks of therapy. We conclude that SMS 201-995 administration is effective treatment for patients with nIST, able to suppress TSH hypersecretion from the adenomatous thyrotrophs and, consequently, to restore clinical and biochemical euthyroidism in such patients. On the contrary, the inhibitory effects of SMS 201-995 on TSH secretion in patients with nnIST are weaker and transient.

Original languageEnglish
Pages (from-to)208-214
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Volume68
Issue number1
Publication statusPublished - 1989

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ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Beck-Peccoz, P., Mariotti, S., Guillausseau, P. J., Medri, G., Piscitelli, G., Bertoli, A., Barbarino, A., Rondena, M., Chanson, P., Pinchera, A., & Faglia, G. (1989). Treatment of hyperthyroidism due to inappropriate secretion of thyrotropin with the somatostatin analog SMS 201-995. Journal of Clinical Endocrinology and Metabolism, 68(1), 208-214.