Il trattamento delle glomerulonefriti immunomediate

The understanding of the immunopathogenesis and genetic basis of the glomerulonephritis has greatly improved in the last three decades. At the same time large trials defined the interaction of factors affecting the rate of deterioration of renal function as interstitial infiltrate, heavy proteinuria, hypertension and initial serum creatinine levels. However, attempts to define the optimal management strategy of different glomerulopathies have been substantially hampered by the extremely variable clinical course that can be seen in these diseases. On these bases it is necessary that the clinician consider the expected duration and outcome of the disease and the risks and benefits of treatment of renal disease before deciding to treat.