Treatment of inappropriate secretion of thyrotropin with somatostatin analog sms 201-995

Paolo Beck-Peccoz, G. Medri, G. Piscitelli, S. Mariotti, A. Bertoli, A. Barbarino, M. Rondena, E. Martino, A. Pinchera, G. Faglia

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Inappropriate thyrotropin secretion (1ST) may originate from either neoplastic disease (nIST) or non-neoplastic resistance to thyroid hormone (nnIST). An inhibitory effect of somatostatin on TSH secretion has been documented. In an attempt to elucidate the possible therapeutic effect of this peptide on nIST and nnIST, a study was conducted in 7 such patients. Sandostatin (SMS 201-995) was administered in daily doses of 100 pg for several days to 1 month. Four patients with nIST responded with a fall in circulating TSH as well as a-subunit with concomitant normalization of free thyroxine and clear symptomatic improvement. In the 3 nnIST patients this effect was considerably less apparent and a partial TSH escape was observed on long-term treatment in 2 cases. The importance of somatostatin and its analogs in the management of thyroid malignancy is stressed.

Original languageEnglish
Pages (from-to)121-123
Number of pages3
JournalHormone Research in Paediatrics
Issue number2-3
Publication statusPublished - 1988


  • Hyperthyroidism
  • Inappropriate secretion of tsh
  • Pituitary resistance
  • Somatostatin
  • Somatostatin analogs
  • Thyroid hormone action
  • TSH-secreting pituitary tumors

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Pediatrics, Perinatology, and Child Health


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