Treatment of intraductal carcinoma of the breast with conservative surgery and radiotherapy: An Italian multicenter retrospective study

M. Amichetti, O. Caffo, A. Richetti, G. Zini, A. Rigon, O. Lora, M. Antonello, M. Arcicasa, M. Roncadin, F. Coghetto, P. Zorat, R. Valdagni, M. Balli, G. Panizzon, S. Maluta, A. Di Marco, S. Favretto, N. Teodorani, S. Neri, S. Fasan

Research output: Contribution to journalArticlepeer-review

Abstract

A collaborative multi-institutional study on intraductal carcinoma (IDC) of the breast in twelve Radiation Oncology Departments of the north Italy was conducted. The study population comprised 206 women with IDC of the breast treated between 1982 and 1992. Surgical procedures were as follows: quadrantectomy in 158, lumpectomy in 34, and wide excision in 14 cases. The axilla was surgically staged in 141 cases: all the patients were node negative. Radiation therapy was delivered with 60Co units (73%) or 6 MV linear accelerators (27%) for a median total dose to the entire breast of 50 Gy (mean, 49.52 Gy). The tumour bed was boosted in 137 cases at a median dose of 10 Gy. Median follow-up is 72 months. Nineteen local recurrences were recorded. All recurrent patients had a salvage mastectomy and are alive and free of disease. Actuarial overall-, cause-specific-, and recurrence-free survivals at 10 years were 93.5%, 100%, and 84%, respectively. The results of this retrospective multicentric study confirm the favourable data reported in the literature about the efficacy of breast conserving treatment of IDC with conservative surgery and adjuvant radiation therapy.

Original languageEnglish
Pages (from-to)109-111
Number of pages3
JournalRadiology and Oncology
Volume31
Issue number2
Publication statusPublished - 1997

Keywords

  • Breast neoplasms
  • Intraductal carcinoma
  • Multicenter studies
  • Treatment options
  • Treatment outcome

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

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