Treatment of isolated secundum atrial septal defects: Impact of age and defect morphology in 1,013 consecutive patients

Gianfranco Butera, Enrico Romagnoli, Mario Carminati, Massimo Chessa, Luciane Piazza, Diana Negura, Alessandro Giamberti, Raul Abella, Giuseppe Pomè, Claudia Condoluci, Alessandro Frigiola

Research output: Contribution to journalArticlepeer-review


Background: Percutaneous closure of atrial septal defect (ASD) is a valid alternative to surgical approach. Current device has significantly improved the success rate also in complex cases. The aim of this study is to assess the impact of age, defect size, and morphologic features on successfully percutaneous ASD closure. Methods: Between January 2000 and September 2004, 1,013 consecutive patients underwent closure of an isolated type II ASD at our institution. The following outcomes have been evaluated: (1) role of percutaneous ASD closure as alternative to surgical repair, in current daily practice; (2) impact of age on the selected closure approach; (3) analysis of morphologic variety of ASD and its effect on the closure technique; (4) possible role of specific device selection according to ASD morphology to improve procedural success. Results: During the study period, up to 80% of secundum ASDs were suitable for percutaneous closure with the currently available devices. Need for surgical ASD closure was more common in pediatric patients, likely reflecting the more frequent diagnosis of larger and complex defects at a young age. Accurate ADS morphology assessment and appropriate device selection are key elements to obtain procedural success. In particular, among all the ASD characteristics, the rim absence is the main limiting factor to a successful percutaneous ASD closure. A trend of reduction in peri-procedural adverse events was observed during the study period, with complications needing immediate cardiac surgery occurred only in 1% of cases. Conclusions: Percutaneous ASD closure is feasible and associated with low complication rate. A thorough analysis of morphologic aspects is mandatory in order to select the appropriate device and the optimal approach. Surgical closure remains the treatment of choice in selected patients.

Original languageEnglish
Pages (from-to)706-712
Number of pages7
JournalAmerican Heart Journal
Issue number4
Publication statusPublished - Oct 2008

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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