Abstract
Background.— In the past few years, several authors have described the usefulness of cultured allogeneic epidermal sheets in promoting wound healing of burns, leg ulcers, and donor sites. This study reports clinical results obtained by different departments in the treatment of chronic leg ulcers by cryopreserved cultured allogeneic epithelium. The freezing procedure and the assessment of viability of the cryopreserved epithelium are also described. A total of 30 ulcers were treated using 138 cryopreserved allografts. Observations.— Twenty ulcers (66.6%) healed completely within 12 weeks. Four ulcers showed a 30% to 84.4% reduction in size by 3 weeks but did not heal completely; the remaining six ulcers did not show any improvement. A strong stimulation of granulation tissue formation and of reepithelialization from the wound edge were observed. Results.— The results indicate that frozen cultured epidermis, stored in a skin bank, is a valid and generally applicable alternative therapy for the treatment of chronic ulcers.
| Original language | English |
|---|---|
| Pages (from-to) | 633-638 |
| Number of pages | 6 |
| Journal | Archives of Dermatology |
| Volume | 128 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1992 |
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ASJC Scopus subject areas
- Dermatology
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Treatment of Leg Ulcers with Cryopreserved Allogeneic Cultured Epithelium : A Multicenter Study. / Luca, Michele; Albanese, Enrico; Cancedda, Ranieri; Viacava, Alberto; Faggioni, Alessandro; Zambruno, Giovanna; Giannetti, Alberto.
In: Archives of Dermatology, Vol. 128, No. 5, 1992, p. 633-638.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Treatment of Leg Ulcers with Cryopreserved Allogeneic Cultured Epithelium
T2 - A Multicenter Study
AU - Luca, Michele
AU - Albanese, Enrico
AU - Cancedda, Ranieri
AU - Viacava, Alberto
AU - Faggioni, Alessandro
AU - Zambruno, Giovanna
AU - Giannetti, Alberto
PY - 1992
Y1 - 1992
N2 - Background.— In the past few years, several authors have described the usefulness of cultured allogeneic epidermal sheets in promoting wound healing of burns, leg ulcers, and donor sites. This study reports clinical results obtained by different departments in the treatment of chronic leg ulcers by cryopreserved cultured allogeneic epithelium. The freezing procedure and the assessment of viability of the cryopreserved epithelium are also described. A total of 30 ulcers were treated using 138 cryopreserved allografts. Observations.— Twenty ulcers (66.6%) healed completely within 12 weeks. Four ulcers showed a 30% to 84.4% reduction in size by 3 weeks but did not heal completely; the remaining six ulcers did not show any improvement. A strong stimulation of granulation tissue formation and of reepithelialization from the wound edge were observed. Results.— The results indicate that frozen cultured epidermis, stored in a skin bank, is a valid and generally applicable alternative therapy for the treatment of chronic ulcers.
AB - Background.— In the past few years, several authors have described the usefulness of cultured allogeneic epidermal sheets in promoting wound healing of burns, leg ulcers, and donor sites. This study reports clinical results obtained by different departments in the treatment of chronic leg ulcers by cryopreserved cultured allogeneic epithelium. The freezing procedure and the assessment of viability of the cryopreserved epithelium are also described. A total of 30 ulcers were treated using 138 cryopreserved allografts. Observations.— Twenty ulcers (66.6%) healed completely within 12 weeks. Four ulcers showed a 30% to 84.4% reduction in size by 3 weeks but did not heal completely; the remaining six ulcers did not show any improvement. A strong stimulation of granulation tissue formation and of reepithelialization from the wound edge were observed. Results.— The results indicate that frozen cultured epidermis, stored in a skin bank, is a valid and generally applicable alternative therapy for the treatment of chronic ulcers.
UR - http://www.scopus.com/inward/record.url?scp=0026633876&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026633876&partnerID=8YFLogxK
U2 - 10.1001/archderm.1992.01680150063007
DO - 10.1001/archderm.1992.01680150063007
M3 - Article
C2 - 1575526
AN - SCOPUS:0026633876
VL - 128
SP - 633
EP - 638
JO - Archives of Dermatology
JF - Archives of Dermatology
SN - 0003-987X
IS - 5
ER -