Treatment of Leg Ulcers with Cryopreserved Allogeneic Cultured Epithelium: A Multicenter Study

Michele Luca, Enrico Albanese, Ranieri Cancedda, Alberto Viacava, Alessandro Faggioni, Giovanna Zambruno, Alberto Giannetti

Research output: Contribution to journalArticlepeer-review


Background.— In the past few years, several authors have described the usefulness of cultured allogeneic epidermal sheets in promoting wound healing of burns, leg ulcers, and donor sites. This study reports clinical results obtained by different departments in the treatment of chronic leg ulcers by cryopreserved cultured allogeneic epithelium. The freezing procedure and the assessment of viability of the cryopreserved epithelium are also described. A total of 30 ulcers were treated using 138 cryopreserved allografts. Observations.— Twenty ulcers (66.6%) healed completely within 12 weeks. Four ulcers showed a 30% to 84.4% reduction in size by 3 weeks but did not heal completely; the remaining six ulcers did not show any improvement. A strong stimulation of granulation tissue formation and of reepithelialization from the wound edge were observed. Results.— The results indicate that frozen cultured epidermis, stored in a skin bank, is a valid and generally applicable alternative therapy for the treatment of chronic ulcers.

Original languageEnglish
Pages (from-to)633-638
Number of pages6
JournalArchives of Dermatology
Issue number5
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Dermatology

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