Treatment of mild to moderate acne with a fixed combination of hydroxypinacolone retinoate, retinol glycospheres and papain glycospheres

S. Veraldi, M. Barbareschi, E. Guanziroli, V. Bettoli, S. Minghetti, B. Capitanio, J. L. Sinagra, P. Sedona, R. Schianchi

Research output: Contribution to journalArticle

Abstract

Aim: A fixed combination of 0.1% hydroxypinacolone retinoate (synthetic esther of 9-cis-retinoic acid), 1% retinol in glycospheres and 2% papain in glycospheres in aqueous gel has been recently introduced into the Italian market in order to reduce the incidence and severity of irritant contact dermatitis caused by topical retinoids, without compromising their efficacy. Primary objectives of this sponsor-free, pilot, open, multicenter study were to evaluate the efficacy and tolerability of this gel in patients with comedonal-papular, mild to moderate acne of the face. Methods: Ninety-eight Caucasian patients (28 males and 70 females), with an age ranging from 15 to 40 years, were treated with the gel once daily for 12 weeks. Acne severity and treatment efficacy were evaluated by means of the Global Acne Grading System (GAGS) and lesions count. Results: Ninety-four patients were considered évaluable. A 41% mean reduction in the GAGS score was observed; a 40.8% mean reduction of total lesions was recorded; 15.3% of patients experienced mild to moderate local side effects (dryness, peeling, erythema, burning). No patients stopped the treatment because of these side effects. Conclusion: This study, based on a high number of évaluable patients, demonstrates that this fixed combination is an effective and safe option for the treatment of comedonal-papular, mild to moderate acne of the face. A controlled clinical study is necessary to confirm these data.

Original languageEnglish
Pages (from-to)143-147
Number of pages5
JournalGiornale Italiano di Dermatologia e Venereologia
Volume150
Issue number2
Publication statusPublished - Apr 1 2015

Fingerprint

Papain
Acne Vulgaris
Vitamin A
Gels
Therapeutics
Irritant Dermatitis
Contact Dermatitis
Retinoids
Erythema
Multicenter Studies
Incidence

Keywords

  • Acne vulgaris
  • Papain
  • Retinoids

ASJC Scopus subject areas

  • Dermatology
  • Medicine(all)

Cite this

Treatment of mild to moderate acne with a fixed combination of hydroxypinacolone retinoate, retinol glycospheres and papain glycospheres. / Veraldi, S.; Barbareschi, M.; Guanziroli, E.; Bettoli, V.; Minghetti, S.; Capitanio, B.; Sinagra, J. L.; Sedona, P.; Schianchi, R.

In: Giornale Italiano di Dermatologia e Venereologia, Vol. 150, No. 2, 01.04.2015, p. 143-147.

Research output: Contribution to journalArticle

Veraldi, S. ; Barbareschi, M. ; Guanziroli, E. ; Bettoli, V. ; Minghetti, S. ; Capitanio, B. ; Sinagra, J. L. ; Sedona, P. ; Schianchi, R. / Treatment of mild to moderate acne with a fixed combination of hydroxypinacolone retinoate, retinol glycospheres and papain glycospheres. In: Giornale Italiano di Dermatologia e Venereologia. 2015 ; Vol. 150, No. 2. pp. 143-147.
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AU - Barbareschi, M.

AU - Guanziroli, E.

AU - Bettoli, V.

AU - Minghetti, S.

AU - Capitanio, B.

AU - Sinagra, J. L.

AU - Sedona, P.

AU - Schianchi, R.

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