Abstract
Deep brain stimulation (DBS) is an established procedure for the symptomatic treatment of Parkinson's disease. Several deep brain nuclei have been stimulated, producing a wide range of effects on the motor and non-motor symptoms of Parkinson's disease. Long-term, high-quality evidence is available for stimulation of the subthalamic nucleus and globus pallidus internus, both of which uniformly improve motor features, and for stimulation of the thalamic ventralis intermedius, which improves tremor. Short-term data are available for stimulation of other deep brain targets, such as the pedunculopontine nucleus and the centremedian/parafascicular thalamic complex. Some non-motor symptoms improve after DBS, partly because of motor benefit or reduction of drug treatment, and partly as a direct effect of stimulation. More evidence on the effects of DBS on non-motor symptoms is needed and specifically designed studies are warranted.
| Original language | English |
|---|---|
| Pages (from-to) | 429-442 |
| Number of pages | 14 |
| Journal | The Lancet Neurology |
| Volume | 11 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May 2012 |
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ASJC Scopus subject areas
- Clinical Neurology
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Treatment of motor and non-motor features of Parkinson's disease with deep brain stimulation. / Fasano, Alfonso; Daniele, Antonio; Albanese, Alberto.
In: The Lancet Neurology, Vol. 11, No. 5, 05.2012, p. 429-442.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Treatment of motor and non-motor features of Parkinson's disease with deep brain stimulation
AU - Fasano, Alfonso
AU - Daniele, Antonio
AU - Albanese, Alberto
PY - 2012/5
Y1 - 2012/5
N2 - Deep brain stimulation (DBS) is an established procedure for the symptomatic treatment of Parkinson's disease. Several deep brain nuclei have been stimulated, producing a wide range of effects on the motor and non-motor symptoms of Parkinson's disease. Long-term, high-quality evidence is available for stimulation of the subthalamic nucleus and globus pallidus internus, both of which uniformly improve motor features, and for stimulation of the thalamic ventralis intermedius, which improves tremor. Short-term data are available for stimulation of other deep brain targets, such as the pedunculopontine nucleus and the centremedian/parafascicular thalamic complex. Some non-motor symptoms improve after DBS, partly because of motor benefit or reduction of drug treatment, and partly as a direct effect of stimulation. More evidence on the effects of DBS on non-motor symptoms is needed and specifically designed studies are warranted.
AB - Deep brain stimulation (DBS) is an established procedure for the symptomatic treatment of Parkinson's disease. Several deep brain nuclei have been stimulated, producing a wide range of effects on the motor and non-motor symptoms of Parkinson's disease. Long-term, high-quality evidence is available for stimulation of the subthalamic nucleus and globus pallidus internus, both of which uniformly improve motor features, and for stimulation of the thalamic ventralis intermedius, which improves tremor. Short-term data are available for stimulation of other deep brain targets, such as the pedunculopontine nucleus and the centremedian/parafascicular thalamic complex. Some non-motor symptoms improve after DBS, partly because of motor benefit or reduction of drug treatment, and partly as a direct effect of stimulation. More evidence on the effects of DBS on non-motor symptoms is needed and specifically designed studies are warranted.
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UR - http://www.scopus.com/inward/citedby.url?scp=84859834372&partnerID=8YFLogxK
U2 - 10.1016/S1474-4422(12)70049-2
DO - 10.1016/S1474-4422(12)70049-2
M3 - Article
C2 - 22516078
AN - SCOPUS:84859834372
VL - 11
SP - 429
EP - 442
JO - The Lancet Neurology
JF - The Lancet Neurology
SN - 1474-4422
IS - 5
ER -