Abstract
BACKGROUND: Nodular prurigo is a chronic dermatitis characterized by very intense pruritus. The treatment is often unsatisfactory. METHODS: Two patients, suffering from chronic, widespread and therapy-resistant nodular prurigo, were treated with cyclosporin in microemulsion. The drug was used orally, at dosage of 3 mg/kg per day for 2 months, followed by 2.5 mg/kg per day for 2 months and by 2 mg/kg per day for 2 months. During the therapy no other topical or systemic drugs were used. RESULTS: In both patients pruritus regressed almost completely within 2 weeks, whereas the morphology of the lesions changed slightly (minimal reduction in infiltration and erythema). The regression of pruritus was followed by a noteworthy improvement in the quality of life. During follow-up, no relapses of pruritus were reported. CONCLUSION: On the basis of this experience, cyclosporin in microemulsion can be successfully used in the treatment of chronic, widespread and therapy-resistant nodular prurigo.
| Original language | English |
|---|---|
| Pages (from-to) | 237-239 |
| Number of pages | 3 |
| Journal | Journal of Dermatological Treatment |
| Volume | 10 |
| Issue number | 4 |
| Publication status | Published - Dec 1999 |
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Keywords
- Cyclosporin
- Cyclosporin in microemulsion
- Nodular prurigo
ASJC Scopus subject areas
- Dermatology
Cite this
Treatment of nodular prurigo with cyclosporin in microemulsion. / Veraldi, S.
In: Journal of Dermatological Treatment, Vol. 10, No. 4, 12.1999, p. 237-239.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Treatment of nodular prurigo with cyclosporin in microemulsion
AU - Veraldi, S.
PY - 1999/12
Y1 - 1999/12
N2 - BACKGROUND: Nodular prurigo is a chronic dermatitis characterized by very intense pruritus. The treatment is often unsatisfactory. METHODS: Two patients, suffering from chronic, widespread and therapy-resistant nodular prurigo, were treated with cyclosporin in microemulsion. The drug was used orally, at dosage of 3 mg/kg per day for 2 months, followed by 2.5 mg/kg per day for 2 months and by 2 mg/kg per day for 2 months. During the therapy no other topical or systemic drugs were used. RESULTS: In both patients pruritus regressed almost completely within 2 weeks, whereas the morphology of the lesions changed slightly (minimal reduction in infiltration and erythema). The regression of pruritus was followed by a noteworthy improvement in the quality of life. During follow-up, no relapses of pruritus were reported. CONCLUSION: On the basis of this experience, cyclosporin in microemulsion can be successfully used in the treatment of chronic, widespread and therapy-resistant nodular prurigo.
AB - BACKGROUND: Nodular prurigo is a chronic dermatitis characterized by very intense pruritus. The treatment is often unsatisfactory. METHODS: Two patients, suffering from chronic, widespread and therapy-resistant nodular prurigo, were treated with cyclosporin in microemulsion. The drug was used orally, at dosage of 3 mg/kg per day for 2 months, followed by 2.5 mg/kg per day for 2 months and by 2 mg/kg per day for 2 months. During the therapy no other topical or systemic drugs were used. RESULTS: In both patients pruritus regressed almost completely within 2 weeks, whereas the morphology of the lesions changed slightly (minimal reduction in infiltration and erythema). The regression of pruritus was followed by a noteworthy improvement in the quality of life. During follow-up, no relapses of pruritus were reported. CONCLUSION: On the basis of this experience, cyclosporin in microemulsion can be successfully used in the treatment of chronic, widespread and therapy-resistant nodular prurigo.
KW - Cyclosporin
KW - Cyclosporin in microemulsion
KW - Nodular prurigo
UR - http://www.scopus.com/inward/record.url?scp=0033374418&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033374418&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0033374418
VL - 10
SP - 237
EP - 239
JO - Journal of Dermatological Treatment
JF - Journal of Dermatological Treatment
SN - 0954-6634
IS - 4
ER -