Treatment of nonmetastatic Ewing's sarcoma family tumors of the spine and sacrum: The experience from a single institution

Gaetano Bacci, Stefano Boriani, Alba Balladelli, Enza Barbieri, Alessandra Longhi, Marco Alberghini, Katia Scotlandi, Cristiana Forni, Paola Pollastri, Daniel Vanel, Mario Mercuri

Research output: Contribution to journalArticlepeer-review

Abstract

The objective of this study is to determine the best local treatment combined with neoadjuvant chemotherapy for ESFT of the spine and sacrum, for the best local treatment for Ewing sarcoma family tumors (ESFT) according to the primary site is still unclear. Nowadays surgery is used in local treatment of ESFT, but literature is scarce on the best local treatment in sites where surgery is problematic, such as the spine. This study evaluates the outcome and the rate of local recurrence of ESFT in the spine and sacrum when treated with neoadjuvant chemotherapy, and locally by radiotherapy alone or surgery, followed by reduced doses of radiotherapy. Forty-three patients with nonmetastatic ESFT located in the spine and sacrum were treated at our institution between 1983 and 2000 with neoadjuvant chemotherapy, and locally by radiotherapy alone in 26 cases, and surgery followed by radiotherapy at reduced doses in 17. The 5- and 10-year event-free survival (EFS) was 37 and 30%, and the 5- and 10-year overall survival was (OS) 42 and 32%. The prognosis was unrelated to gender and age, tumor volume, chemotherapy protocol, and local treatment. The outcome seemed worse for patients with primary tumors located in the sacrum than for patients with tumors located in the rest of the spine (5-year EFS = 23 vs. 46%). For these patients the results were significantly worse than for those we achieved with neoadjuvant treatment for ESFT located in other sites. However, no differences were observed between patients locally treated with radiotherapy alone and those treated by radiotherapy followed by surgery. We concluded that regardless of the type of local treatment even when associated with neoadjuvant therapy, ESFT in the spine and sacrum has a poor outcome and prognosis is significantly worse than that of primary ESFT in other sites.

Original languageEnglish
Pages (from-to)1091-1095
Number of pages5
JournalEuropean Spine Journal
Volume18
Issue number8
DOIs
Publication statusPublished - Aug 2009

Keywords

  • Ewing's sarcoma family tumors
  • Neoadjuvant chemotherapy
  • Radiotherapy
  • Spine and sacrum
  • Surgery

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

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