Treatment of obstetric and gynecologic infections with meropenem: Comparison with imipenem/cilastatin

P. Maggioni, F. Di Stefano, V. Facchini, S. Irato, S. Mancuso, M. Colombo, M. Massobrio, G. B. Melis, P. Crosignani

Research output: Contribution to journalArticle

Abstract

The aim of this study was to compare the clinical and bacteriologic efficacy of meropenem with imipenem/cilastatin in the treatment of obstetric and gynecologic infections. This was a controlled, multicenter, randomized study with two parallel groups and a follow-up period of up to 4 weeks. A total of 105 hospital in-patients requiring antibacterial parenteral therapy were enrolled; 52 in the meropenem group and 53 in the imipenem/cilastatin group. Both drugs were administered at 0.59 every 8 hours, by slow intravenous infusion over 20-30 minutes; for meropenem the administration by intravenous bolus injection (over approximately 5 minutes) was allowed. The mean duration of therapy was 5 days for both treatments. At the end of treatment, all 46 evaluable patients in the meropenem treatment group had a satisfactory clinical response, while in the imipenem/cilastatin group 5/49 patients were clinical failures. The difference between the treatment groups in clinical response was statistically significant (100% vs 89.8%; p = 0.026). A similar result was seen in the intention-to-treat analysis (98% vs 84.6%; p = 0.017). Both treatments were well tolerated, but fewer meropenem patients experienced treatment-related adverse events in comparison with imipenem/cilastatin (11.5% vs 15.1%).

Original languageEnglish
Pages (from-to)114-121
Number of pages8
JournalJournal of Chemotherapy
Volume10
Issue number2
Publication statusPublished - 1998

Keywords

  • Cilastatin
  • Imipenem
  • Infection
  • Meropenem
  • Obstetric and gynecologic

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Microbiology (medical)

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    Maggioni, P., Di Stefano, F., Facchini, V., Irato, S., Mancuso, S., Colombo, M., Massobrio, M., Melis, G. B., & Crosignani, P. (1998). Treatment of obstetric and gynecologic infections with meropenem: Comparison with imipenem/cilastatin. Journal of Chemotherapy, 10(2), 114-121.