Treatment of oropharyngeal candidiasis in HIV-infected children with oral fluconazole

P. Marchisio, N. Principi

Research output: Contribution to journalArticle

Abstract

In an open, noncomparative, multicentre study the efficacy and safety of oral fluconazole was evaluated in the treatment of oropharyngeal candidiasis in children with HIV infection. Fifty-one children with a mean age of five years were enrolled. Oropharyngeal candidiasis was caused by Candida albicans in 28 cases (55 %). Fluconazole was given in a mean dosage of 3.4 mg/kg/d (range 2 to 5.6 mg/kg/d) for a mean duration of 12 days (range 6 to 28 days). By the end of treatment, 90 % of the children were clinically cured, 6 % had improved and 4 % failed to respond. Candida was eradicated in 82 % of the patients. Clinical failure occurred only in children given 3 mg/kg/d or less. Two and four weeks after therapy, clinical cure was confirmed in 88 % and 82 % of the children respectively as well as eradication in 76 % respectively. Six children experienced mild side effects (1 skin rash, 5 mild elevation of liver enzyme levels). The data show that fluconazole is safe and effective in treating oropharyngeal candidiasis in HIV-infected children.

Original languageEnglish
Pages (from-to)338-340
Number of pages3
JournalEuropean Journal of Clinical Microbiology and Infectious Diseases
Volume13
Issue number4
DOIs
Publication statusPublished - Apr 1994

ASJC Scopus subject areas

  • Microbiology (medical)
  • Immunology

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