Treatment of pregnancy complications

Barbara Acaia, Federica Rossi, Cecilia Beatrice Chighizola

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Pregnancy morbidity and vascular thrombosis provide the clinical manifestations of the antiphospholipid syndrome (APS), a chronic autoimmune condition serologically characterized by the positivity of antiphospholipid antibodies (aPL). Antiplatelet and anticoagulant agents currently provide the mainstay of the treatment of obstetric APS. However, the debate is still open: controversies involve the management of rare aPL-mediated obstetric complications, the treatment of vascular manifestations, and the treatment of refractory cases. Unfortunately, the literature cannot provide definite answers to these controversial issues as it is flawed by many limitations, mainly due to the recruitment of patients not fulfilling laboratory and clinical criteria for APS. In addition, no treatment trial has ever investigated the optimal treatment of aPL women stratifying upon the different risk profile (aPL profile, associated autoimmune disease, previous obstetrical history). The recommended therapeutic managements of different aPL-related obstetrical clinical manifestations are hereby presented, with a critical appraisal of the evidence supporting each approach.

Original languageEnglish
Title of host publicationAntiphospholipid Antibody Syndrome: From Bench to Bedside
PublisherSpringer International Publishing
Pages193-206
Number of pages14
ISBN (Print)9783319110448, 9783319110431
DOIs
Publication statusPublished - Jan 1 2015

Keywords

  • Antiphospholipid syndrome
  • Pregnancy morbidity
  • Treatment

ASJC Scopus subject areas

  • Medicine(all)

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