Background/Aims: This study aims at evaluating the efficacy of treatment with pegylated interferon (PEG-IFN) alfa-2b and ribavirin in patients with recurrent hepatitis C (genotype 1) after orthotopic liver transplantation (OLT) and the impact of this therapy on hepatic fibrosis at the end of conventional therapy and at the end of a period of maintenance treatment in non-responder patients. Methodology: Thirty-two consecutive patients diagnosed with recurrent HCV were considered candidates for antiviral therapy. Results: Ten patients (31.2%) interrupted therapy due to side effects; sustained virological response (SVR) was observed in 27.2%, sustained biochemical response (SBR) in 31.8% and NR in 40.9% of cases. Eighteen patients underwent a biopsy at the end of conventional treatment: improved fibrosis score in all patients with SVR, improved score in 1 patient with SBR and stable score in 6 patients with SBR, worse score in 1 NR patient and stable in 6 NR patients. Six NR patients with stable score submitted to a maintenance therapy: improved score in 1 patient and stable score in 5 patients. Conclusions: In recurrent hepatitis C, in spite of the type of response, treatment slows down hepatic fibrotic evolution.
|Number of pages||3|
|Publication status||Published - Mar 2011|
- Maintenance therapy
- Orthotopic liver transplantation
- Pegylated interferon
- Recurrent hepatitis C
ASJC Scopus subject areas