TY - JOUR
T1 - Treatment of recurrent hepatocellular carcinoma with sorafenib in a HIV/HCV Co-infected patient in HAART
T2 - A case report
AU - De Nardo, Pasquale
AU - Viscione, Magdalena
AU - Corpolongo, Angela
AU - Bellagamba, Rita
AU - Vennarecci, Giovanni
AU - Ettorre, Giuseppe Maria
AU - Gentilotti, Elisa
AU - Tommasi, Chiara
AU - Nicastri, Emanuele
PY - 2012
Y1 - 2012
N2 - Background: Liver disease is the second cause of death among HIV patients receiving highly active antiretroviral therapy (HAART) in Europe. HIV patients have a high prevalence of chronic HBV (6-10%) and HCV (33%) co-infection, and accelerated progression of viral hepatitis. Furthermore, the long duration of both HIV and HCV diseases in the HAART era increases the risk of hepatocellular carcinoma. Findings. We report the case of a 49year -old HIV/HCV co-infected male patient who developed hepatocellular carcinoma. The patient underwent a partial hepatectomy, and a few months later was treated with transcatheter arterial chemoembolisation due to hepatocarcinoma recurrence. Two months later, advanced hepatocellular carcinoma was diagnosed and sorafenib therapy was initiated. The patient achieved partial response of the main lesions, complete regression of the smallest lesions and did not experience clinical progression during the 20-month follow-up period. During therapy with sorafenib, the patient was treated with HAART with good viral and immunological responses. We used the therapeutic drug monitoring to assess antiretroviral concentrations during co-administration of sorafenib. Fosamprenavir Ctrough was found under the minimum level recommended by international guidelines. No grade 3 or 4 toxicities were observed. At month 20 of treatment, new liver lesions with portal vein thrombosis were diagnosed. After 28months of sorafenib therapy, the patient deceased for severe liver insufficiency. Conclusions: Sorafenib monotherapy demonstrated a marked delay in HCC disease progression in an HIV/HCV co-infected patient. Fosamprenavir Ctrough was found under the minimum level recommended by international guidelines, suggesting a possible interaction.
AB - Background: Liver disease is the second cause of death among HIV patients receiving highly active antiretroviral therapy (HAART) in Europe. HIV patients have a high prevalence of chronic HBV (6-10%) and HCV (33%) co-infection, and accelerated progression of viral hepatitis. Furthermore, the long duration of both HIV and HCV diseases in the HAART era increases the risk of hepatocellular carcinoma. Findings. We report the case of a 49year -old HIV/HCV co-infected male patient who developed hepatocellular carcinoma. The patient underwent a partial hepatectomy, and a few months later was treated with transcatheter arterial chemoembolisation due to hepatocarcinoma recurrence. Two months later, advanced hepatocellular carcinoma was diagnosed and sorafenib therapy was initiated. The patient achieved partial response of the main lesions, complete regression of the smallest lesions and did not experience clinical progression during the 20-month follow-up period. During therapy with sorafenib, the patient was treated with HAART with good viral and immunological responses. We used the therapeutic drug monitoring to assess antiretroviral concentrations during co-administration of sorafenib. Fosamprenavir Ctrough was found under the minimum level recommended by international guidelines. No grade 3 or 4 toxicities were observed. At month 20 of treatment, new liver lesions with portal vein thrombosis were diagnosed. After 28months of sorafenib therapy, the patient deceased for severe liver insufficiency. Conclusions: Sorafenib monotherapy demonstrated a marked delay in HCC disease progression in an HIV/HCV co-infected patient. Fosamprenavir Ctrough was found under the minimum level recommended by international guidelines, suggesting a possible interaction.
KW - Fosamprenavir
KW - HAART
KW - Hepatocarcinoma
KW - HIV/HCV co-infection
KW - Sorafenib
KW - TDM
UR - http://www.scopus.com/inward/record.url?scp=84862774798&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862774798&partnerID=8YFLogxK
U2 - 10.1186/1750-9378-7-15
DO - 10.1186/1750-9378-7-15
M3 - Article
C2 - 22741810
AN - SCOPUS:84862774798
VL - 7
JO - Infectious Agents and Cancer
JF - Infectious Agents and Cancer
SN - 1750-9378
IS - 1
M1 - 15
ER -