Treatment of respiratory tract infections in children: A study of a combination of amoxycillin and clavulanic acid

A. Fiocchi, G. Zuccotti, R. Bellu, P. Marangione, E. Riva, M. Giovannini

Research output: Contribution to journalArticlepeer-review

Abstract

In an open study, 70 in-patients and 23 out-patients aged between 1 and 14 years with sinusitis (n = 1), perforated otitis media (n = 4), pharyngotonsillitis (n = 25), tracheobronchitis (n = 30) or bronchopneumonia (n = 33) were treated daily with a combination of 40 mg/kg amoxycillin and 10 mg/kg clavulanic acid in three equal doses for between 6 and 15 days. Purulent specimens were cultured when obtainable and pathogenic organisms identified were Staphylococcus aureus, β-haemolytic streptococcal group A, Pseudomonas aeruginosa, Pseudococcus species and Klebsiella pneumoniae infections, of which 45.7% were β-lactamase-producing and 54.3% were ampicillin-susceptible. After treatment, only one β-lactamase-producing Streptococcus and one Staphylococcus infection persisted. Side-effects (vomiting, nausea, diarrhoea, maculopapular exanthema, rash) occurred in 16 patients and treatment was withdrawn in eight. It is concluded that the amoxycillin-clavulanic acid combination is a suitable first choice for the treatment of respiratory tract infections in children in whom the pathogenic organism may not have been established.

Original languageEnglish
Pages (from-to)326-333
Number of pages8
JournalJournal of International Medical Research
Volume18
Issue number4
Publication statusPublished - 1990

Keywords

  • Amoxycillin
  • children
  • clavulanic acid
  • respiratory tract infections

ASJC Scopus subject areas

  • Medicine(all)

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