Treatment of respiratory tract infections in children: A study of a combination of amoxycillin and clavulanic acid

A. Fiocchi, G. Zuccotti, R. Bellu, P. Marangione, E. Riva, M. Giovannini

Research output: Contribution to journalArticle

Abstract

In an open study, 70 in-patients and 23 out-patients aged between 1 and 14 years with sinusitis (n = 1), perforated otitis media (n = 4), pharyngotonsillitis (n = 25), tracheobronchitis (n = 30) or bronchopneumonia (n = 33) were treated daily with a combination of 40 mg/kg amoxycillin and 10 mg/kg clavulanic acid in three equal doses for between 6 and 15 days. Purulent specimens were cultured when obtainable and pathogenic organisms identified were Staphylococcus aureus, β-haemolytic streptococcal group A, Pseudomonas aeruginosa, Pseudococcus species and Klebsiella pneumoniae infections, of which 45.7% were β-lactamase-producing and 54.3% were ampicillin-susceptible. After treatment, only one β-lactamase-producing Streptococcus and one Staphylococcus infection persisted. Side-effects (vomiting, nausea, diarrhoea, maculopapular exanthema, rash) occurred in 16 patients and treatment was withdrawn in eight. It is concluded that the amoxycillin-clavulanic acid combination is a suitable first choice for the treatment of respiratory tract infections in children in whom the pathogenic organism may not have been established.

Original languageEnglish
Pages (from-to)326-333
Number of pages8
JournalJournal of International Medical Research
Volume18
Issue number4
Publication statusPublished - 1990

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Amoxicillin-Potassium Clavulanate Combination
Clavulanic Acid
Amoxicillin
Ampicillin
Respiratory Tract Infections
Exanthema
Klebsiella Infections
Bronchopneumonia
Sinusitis
Otitis Media
Klebsiella pneumoniae
Streptococcus
Staphylococcus
Pseudomonas aeruginosa
Nausea
Vomiting
Staphylococcus aureus
Diarrhea
Outpatients
Therapeutics

Keywords

  • Amoxycillin
  • children
  • clavulanic acid
  • respiratory tract infections

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Treatment of respiratory tract infections in children : A study of a combination of amoxycillin and clavulanic acid. / Fiocchi, A.; Zuccotti, G.; Bellu, R.; Marangione, P.; Riva, E.; Giovannini, M.

In: Journal of International Medical Research, Vol. 18, No. 4, 1990, p. 326-333.

Research output: Contribution to journalArticle

Fiocchi, A. ; Zuccotti, G. ; Bellu, R. ; Marangione, P. ; Riva, E. ; Giovannini, M. / Treatment of respiratory tract infections in children : A study of a combination of amoxycillin and clavulanic acid. In: Journal of International Medical Research. 1990 ; Vol. 18, No. 4. pp. 326-333.
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