Prise en charge thérapeutique de la rosacée

Translated title of the contribution: Treatment of rosacea

A. Parodi, F. Drago, S. Paolino, E. Cozzani, R. Gallo

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A range of treatment options are available in rosacea, which include several topical (mainly metronidazole, azelaic acid, other antibiotics, sulfur, retinoids) and oral drugs (mainly tetracyclines, metronidazole, macrolides). In some cases, the first choice is a systemic therapy because patients may have sensitive skin and topical medications can be irritant. Isotretinoin can be used in resistant cases of rosacea. Unfortunately, the majority of studies on rosacea treatments are at high or unclear risk of bias. A recent Cochrane review found that only topical metronidazole, azelaic acid, and oral doxycycline (40 mg) had some evidence to support their effectiveness in moderate to severe rosacea and concluded that further well-designed, adequately-powered randomised controlled trials are required. In our practice, we evaluate our patients for the presence of two possible triggers, Helicobacter pylori infection and small intestinal bacterial overgrowth. When they are present we use adapted antibiotic protocols. If not, we use oral metronidazole or oral tetracycline to treat papulopustolar rosacea. We also look for Demodex folliculorum infestation. When Demodex concentration is higher than 5/cm 2 we use topical crotamiton 10% or metronidazole.

Original languageFrench
JournalAnnales de Dermatologie et de Venereologie
Volume138
Issue numberSUPPL. 2
DOIs
Publication statusPublished - Sep 2011

Fingerprint

Rosacea
Metronidazole
Anti-Bacterial Agents
Therapeutics
Tetracyclines
Isotretinoin
Doxycycline
Irritants
Macrolides
Retinoids
Helicobacter Infections
Tetracycline
Sulfur
Helicobacter pylori
Randomized Controlled Trials
Skin
Pharmaceutical Preparations

Keywords

  • Azelaic acid
  • Crotamiton
  • Metronidazole
  • Rosacea
  • Tetracyclines

ASJC Scopus subject areas

  • Dermatology

Cite this

Prise en charge thérapeutique de la rosacée. / Parodi, A.; Drago, F.; Paolino, S.; Cozzani, E.; Gallo, R.

In: Annales de Dermatologie et de Venereologie, Vol. 138, No. SUPPL. 2, 09.2011.

Research output: Contribution to journalArticle

Parodi, A. ; Drago, F. ; Paolino, S. ; Cozzani, E. ; Gallo, R. / Prise en charge thérapeutique de la rosacée. In: Annales de Dermatologie et de Venereologie. 2011 ; Vol. 138, No. SUPPL. 2.
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