Treatment of severe diabetic acidosis with tris-hydroxymethyl aminomethane in a thirteen-year-old child

Marco Marano, F. Iodice, F. Stoppa, C. Tomasello, D. Perrotta, C. Cecchetti, M. Di Nardo, P. Ciampalini, N. Pirozzi

Research output: Contribution to journalArticlepeer-review

Abstract

Diabetic ketoacidosis is a severe complication of type I diabetes. A 13-year-old female (40 kg) patient was admitted to our Intensive Care Unit with severe metabolic acidosis (pH: 6.8), hyperglycemia (835 mg/dL) and coma. Her hemodynamic conditions were unstable and, even though a large amount of plasma expanders, crystalloids, and inotropic support were supplied, the patient went into cardiac arrest in the first hour of treatment. After resuscitation, a better hemodynamic balance was achieved and metabolic acidosis was treated with fluid replacement therapy, continuous insulin infusion, and Tris-hydroxymethyl aminomethane (THAM) as a buffering agent. This therapy rapidly improved her metabolic conditions. The patient was discharged 5 days after Intensive Care Unit admission in good condition and without neurological sequelae.

Original languageEnglish
Pages (from-to)93-95
Number of pages3
JournalMinerva Anestesiologica
Volume74
Issue number3
Publication statusPublished - Mar 2008

Keywords

  • Diabetes mellitus
  • Diabetic ketoacidosis, diagnosis
  • Diabetic ketoacidosis, drug therapy

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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