Treatment of severe pulmonary hypertension secondary to scleroderma: A three-drug approach

Girolamo Catapano-Minotti, Andrea Corsonello, Giovanni Guadalupi, Rosalia Spani, Raffaele Antonelli-Incalzi

Research output: Contribution to journalArticlepeer-review

Abstract

We present a case of scleroderma complicated by severe pulmonary hypertension. The use of a three-drug (bosentan, iloprost, and sildenafil) approach contributed to significant improvement of both the clinical conditions and the pulmonary hemodynamics. Combining three pulmonary vasodilators with different mechanisms of action could benefit patients with severe pulmonary hypertension resistant to conventional therapy.

Original languageEnglish
Pages (from-to)511-513
Number of pages3
JournalInternal Medicine
Volume47
Issue number6
DOIs
Publication statusPublished - 2008

Keywords

  • Bosentan
  • Iloprost
  • Pulmonary hypertension
  • Scleroderma
  • Sildenafil

ASJC Scopus subject areas

  • Internal Medicine
  • Medicine(all)

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