TY - JOUR
T1 - Treatment of the first tonic-clonic seizure does not affect long-term remission of epilepsy
AU - Leone, Maurizio A.
AU - Solari, Alessandra
AU - Beghi, Ettore
PY - 2006/12
Y1 - 2006/12
N2 - We followed 419 patients with a first, unprovoked, primarily or secondarily generalized tonic-clonic seizure, randomized to immediate antiepileptic treatment or to treatment only in the event of seizure recurrence. The probability of achieving a 2-year remission was 72 vs 57% at 3 months, 84 to 79% at 3 years, and 85 to 86% at 10 years (p = NS). The probability of entering 5-year remission was 47 to 40, 58 to 58, and 64 to 64% (p = NS). Early treatment does not affect the long-term prognosis of epilepsy.
AB - We followed 419 patients with a first, unprovoked, primarily or secondarily generalized tonic-clonic seizure, randomized to immediate antiepileptic treatment or to treatment only in the event of seizure recurrence. The probability of achieving a 2-year remission was 72 vs 57% at 3 months, 84 to 79% at 3 years, and 85 to 86% at 10 years (p = NS). The probability of entering 5-year remission was 47 to 40, 58 to 58, and 64 to 64% (p = NS). Early treatment does not affect the long-term prognosis of epilepsy.
UR - http://www.scopus.com/inward/record.url?scp=33845928660&partnerID=8YFLogxK
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U2 - 10.1212/01.wnl.0000249309.80510.63
DO - 10.1212/01.wnl.0000249309.80510.63
M3 - Article
C2 - 17190950
AN - SCOPUS:33845928660
VL - 67
SP - 2227
EP - 2229
JO - Neurology
JF - Neurology
SN - 0028-3878
IS - 12
ER -