Treatment of the first tonic-clonic seizure does not affect long-term remission of epilepsy

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Abstract

We followed 419 patients with a first, unprovoked, primarily or secondarily generalized tonic-clonic seizure, randomized to immediate antiepileptic treatment or to treatment only in the event of seizure recurrence. The probability of achieving a 2-year remission was 72 vs 57% at 3 months, 84 to 79% at 3 years, and 85 to 86% at 10 years (p = NS). The probability of entering 5-year remission was 47 to 40, 58 to 58, and 64 to 64% (p = NS). Early treatment does not affect the long-term prognosis of epilepsy.

Original languageEnglish
Pages (from-to)2227-2229
Number of pages3
JournalNeurology
Volume67
Issue number12
DOIs
Publication statusPublished - Dec 2006

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Epilepsy
Seizures
Anticonvulsants
Therapeutics
Recurrence

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

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abstract = "We followed 419 patients with a first, unprovoked, primarily or secondarily generalized tonic-clonic seizure, randomized to immediate antiepileptic treatment or to treatment only in the event of seizure recurrence. The probability of achieving a 2-year remission was 72 vs 57{\%} at 3 months, 84 to 79{\%} at 3 years, and 85 to 86{\%} at 10 years (p = NS). The probability of entering 5-year remission was 47 to 40, 58 to 58, and 64 to 64{\%} (p = NS). Early treatment does not affect the long-term prognosis of epilepsy.",
author = "Leone, {Maurizio A.} and Alessandra Solari and Ettore Beghi",
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AB - We followed 419 patients with a first, unprovoked, primarily or secondarily generalized tonic-clonic seizure, randomized to immediate antiepileptic treatment or to treatment only in the event of seizure recurrence. The probability of achieving a 2-year remission was 72 vs 57% at 3 months, 84 to 79% at 3 years, and 85 to 86% at 10 years (p = NS). The probability of entering 5-year remission was 47 to 40, 58 to 58, and 64 to 64% (p = NS). Early treatment does not affect the long-term prognosis of epilepsy.

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