Treatment of triple negative breast cancer (TNBC): Current options and future perspectives

M. De Laurentiis, D. Cianniello, R. Caputo, B. Stanzione, G. Arpino, S. Cinieri, V. Lorusso, S. De Placido

Research output: Contribution to journalArticle

Abstract

Breast cancer is not considered anymore a unique disease. Microarray gene expression analysis led to the identification of 4 major breast cancer 'intrinsic ' subtypes, including hormone receptor (HR)-positive luminal A and B, human epidermal growth receptor 2 (HER2)-positive and basal-like breast cancer (BLBC). These subtypes have distinct phenotypes, molecular profiles, clinical behaviour and response to therapy, with the BLBC carrying the worst outcome. Microarray analysis is not feasible in routine practice and therefore oncologists rely on a simpler immunohistochemical (IHC) classification to identify relevant breast cancer subtypes. Triple negative breast cancer (TNBC) is defined by the absence of oestrogen receptor, progesterone receptor and HER2 expression at IHC analysis. TNBC is strictly related to BLBC and, given the lack of common therapeutic targets, represent a major challenge for breast oncologist. In this review we will summarize the updated knowledge on TNBC, with emphasis on its current treatment and on the new therapeutic options under development.

Original languageEnglish
JournalCancer Treatment Reviews
Volume36
Issue numberSUPPL. 3
DOIs
Publication statusPublished - Nov 2010

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Keywords

  • Antiangiogenics
  • Basal-like
  • Breast cancer
  • EGFR inhibitors
  • PARP inhibitors
  • Triple negative

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

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