Treatment of Wernicke's encephalopathy with high dose of thiamine in a patient with pyloric sub-stenosis: Description of a case

Francesca Caso, A. Fiorino, M. Falautano, L. Leocani, V. Martinelli, F. Minicucci, A. Falini, G. Comi, G. Magnani

Research output: Contribution to journalArticlepeer-review

Abstract

Wernicke's encephalopathy (WE) is an acute or subacute syndrome that results from a deficiency in vitamin B1 (thiamine). The syndrome is characterised by a classical triad of symptoms: nystagmus and ophthalmoplegia, mental-status changes, and unsteadiness of stance and gait. When patients with WE are inappropriately treated with low doses of thiamine, mortality rates average out at 20% and Korsakoff's Psychosis develops in about 85% of survivors (Sechi and Serra in Lancet Neurol 6(5):442-455, 2007). We report the case of a patient with a pyloric sub-stenosis that developed a WE, and was treated with high doses of thiamine showing after few days of treatment a great improvement of neurological and neuroradiological assessment, even though cognitive impairment was still severe at discharge and at 6 months follow-up.

Original languageEnglish
Pages (from-to)859-861
Number of pages3
JournalNeurological Sciences
Volume31
Issue number6
DOIs
Publication statusPublished - Dec 2010

Keywords

  • Pyloric sub-stenosis
  • Thiamine therapy
  • Wernicke's encephalopathy

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology

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