TY - JOUR
T1 - Treatment of Wernicke's encephalopathy with high dose of thiamine in a patient with pyloric sub-stenosis
T2 - Description of a case
AU - Caso, Francesca
AU - Fiorino, A.
AU - Falautano, M.
AU - Leocani, L.
AU - Martinelli, V.
AU - Minicucci, F.
AU - Falini, A.
AU - Comi, G.
AU - Magnani, G.
PY - 2010/12
Y1 - 2010/12
N2 - Wernicke's encephalopathy (WE) is an acute or subacute syndrome that results from a deficiency in vitamin B1 (thiamine). The syndrome is characterised by a classical triad of symptoms: nystagmus and ophthalmoplegia, mental-status changes, and unsteadiness of stance and gait. When patients with WE are inappropriately treated with low doses of thiamine, mortality rates average out at 20% and Korsakoff's Psychosis develops in about 85% of survivors (Sechi and Serra in Lancet Neurol 6(5):442-455, 2007). We report the case of a patient with a pyloric sub-stenosis that developed a WE, and was treated with high doses of thiamine showing after few days of treatment a great improvement of neurological and neuroradiological assessment, even though cognitive impairment was still severe at discharge and at 6 months follow-up.
AB - Wernicke's encephalopathy (WE) is an acute or subacute syndrome that results from a deficiency in vitamin B1 (thiamine). The syndrome is characterised by a classical triad of symptoms: nystagmus and ophthalmoplegia, mental-status changes, and unsteadiness of stance and gait. When patients with WE are inappropriately treated with low doses of thiamine, mortality rates average out at 20% and Korsakoff's Psychosis develops in about 85% of survivors (Sechi and Serra in Lancet Neurol 6(5):442-455, 2007). We report the case of a patient with a pyloric sub-stenosis that developed a WE, and was treated with high doses of thiamine showing after few days of treatment a great improvement of neurological and neuroradiological assessment, even though cognitive impairment was still severe at discharge and at 6 months follow-up.
KW - Pyloric sub-stenosis
KW - Thiamine therapy
KW - Wernicke's encephalopathy
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U2 - 10.1007/s10072-010-0253-1
DO - 10.1007/s10072-010-0253-1
M3 - Article
C2 - 20390435
AN - SCOPUS:78650515878
VL - 31
SP - 859
EP - 861
JO - Neurological Sciences
JF - Neurological Sciences
SN - 1590-1874
IS - 6
ER -