Treatment strategy for rectal cancer with synchronous metastasis: 65 consecutive italian cases from the bologna multidisciplinary rectal cancer group

Carmine Pinto, Sara Pini, Francesca Di Fabio, Dajana Cuicchi, Bruno Iacopino, Ferdinando Lecce, Giorgio Ercolani, Fabiola Lorena Rojas Llimpe, Emilio De Raffele, Franco Stella, Piergiorgio Di Tullio, Stefania Giaquinta, Antonio Daniele Pinna, Bruno Cola

Research output: Contribution to journalArticle

Abstract

Background: Twenty percent of rectal cancer patients have synchronous distant metastasis at diagnosis. At present, the treatment strategy in this patient setting is not well defined. This study in one institution evaluates the treatment strategy of three different patient groups. Patients and Methods: Between January 2000 and July 2011, 65 patients with M1 rectal cancer were evaluated. Three different groups were defined: rectal cancer with resectable metastatic disease (group A); rectal cancer with potentially resectable metastatic disease (group B), and rectal cancer with unresectable metastatic disease (group C). Results: Group A included 11 patients (16.9%), group B 28 patients (43.1%) and group C 26 patients (40%). Forty-three (66.2%) patients underwent surgery for primary rectal cancer, and 30 (46.2%) patients for metastasis resection (23 liver, 4 lung and 3 ovary). Median overall survival (OS) by group was: 51 (5-86; group A), 32 (24-40; group B) and 16 (7-26; group C) months. Patients undergoing metastasis resection have higher median OS than unresected patients (44 vs. 15 months; p <0.001). Conclusions: The treatment strategy in synchronous metastatic rectal cancer must consider the possibility of distant metastasis resection. Long-term survival can be achieved using an integrated approach.

Original languageEnglish
Pages (from-to)135-142
Number of pages8
JournalOncology
Volume86
Issue number3
DOIs
Publication statusPublished - 2014

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Keywords

  • Chemoradiotherapy
  • Conversion chemotherapy
  • Rectal cancer
  • Synchronous metastasis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Pinto, C., Pini, S., Di Fabio, F., Cuicchi, D., Iacopino, B., Lecce, F., Ercolani, G., Rojas Llimpe, F. L., De Raffele, E., Stella, F., Di Tullio, P., Giaquinta, S., Pinna, A. D., & Cola, B. (2014). Treatment strategy for rectal cancer with synchronous metastasis: 65 consecutive italian cases from the bologna multidisciplinary rectal cancer group. Oncology, 86(3), 135-142. https://doi.org/10.1159/000357782