Treatment trends in metastatic pancreatic cancer patients: Is it time to change?

Michele Reni, Lara Maria Pasetto, Alessandro Passardi, Michele Milella, Andrea Mambrini, Stefano Cereda, Giuseppe Aprile, Maria Chiara Tronconi, Rossana Berardi, Stefano Cordio, Nora Sartori, Alessia Rognone, Paolo Pederzoli, Massimo Falconi

Research output: Contribution to journalArticle

Abstract

Background: Since gemcitabine became the standard treatment for metastatic pancreatic adenocarcinoma, combination chemotherapy obtained conflicting impact on survival (OS). Aims: To evaluate Italian treatment trends in metastatic pancreatic cancer. Methods: Data on treatment outcome of 943 chemo-naive patients with pathological diagnosis of stage IV pancreatic adenocarcinoma treated between 1997 and 2007 in Italian centres were analysed. Results: Four treatment groups could be identified: (1) single agent gemcitabine (n=529); (2) gemcitabine-platinating agent doublets (n=105); (3) gemcitabine-free three-drug intraarterial combination (n=75); (4) four-drug gemcitabine-cisplatin-fluoropyrimidine based combinations (n=170).Median and actuarial 1. y OS of the whole population were 6.2 months and 20%, respectively. Gemcitabine (median OS 5.1 months) appeared significantly inferior to gemcitabine-free triplets (median OS 6.0 months; p=04), gemcitabine-platinating agent doublets (median OS 7.4 months; p=00001), or gemcitabine-based four drug combinations (median OS 9.1 months; p

Original languageEnglish
Pages (from-to)225-230
Number of pages6
JournalDigestive and Liver Disease
Volume43
Issue number3
DOIs
Publication statusPublished - Mar 2011

Keywords

  • Chemotherapy
  • Gemcitabine
  • Pancreatic cancer
  • Survey

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

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  • Cite this

    Reni, M., Pasetto, L. M., Passardi, A., Milella, M., Mambrini, A., Cereda, S., Aprile, G., Tronconi, M. C., Berardi, R., Cordio, S., Sartori, N., Rognone, A., Pederzoli, P., & Falconi, M. (2011). Treatment trends in metastatic pancreatic cancer patients: Is it time to change? Digestive and Liver Disease, 43(3), 225-230. https://doi.org/10.1016/j.dld.2010.09.010