Treatment with citicoline eye drops enhances retinal function and neural conduction along the visual pathways in open angle glaucoma

Vincenzo Parisi, Marco Centofanti, Lucia Ziccardi, Lucia Tanga, Manuele Michelessi, Gloria Roberti, Gianluca Manni

Research output: Contribution to journalArticle


Purpose: To evaluate the retinal function and the neural conduction along the visual pathways after treatment with citicoline eye drops in patients with open angle glaucoma (OAG). Methods: Fifty-six OAG patients (mean age 52.4 ± 4.72 years, IOP 0.01) PERG and VEP values in GC and GP eyes were observed. After treatment with topical citicoline, a significant (p <0.01) increase of PERG P50-N95 and VEP N75-P100 amplitudes, and a significant (p <0.01) shortening of VEP P100 implicit times were found. In GC eyes, the shortening of VEP P100 implicit times was correlated significantly (p <0.01) with the increase of PERG P50-N95 amplitudes. After a 2-month period of topical Citicoline wash-out, PERG and VEP values were similar (p > 0.01) to baseline ones. GP eyes showed not significant changes of PERG and VEP values during the entire follow-up. Conclusions: Topical treatment with citicoline in OAG eyes induces an enhancement of the retinal bioelectrical responses (increase of PERG amplitude) with a consequent improvement of the bioelectrical activity of the visual cortex (shortening and increase of VEP implicit time and amplitude, respectively).

Original languageEnglish
Pages (from-to)1327-1340
Number of pages14
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Issue number8
Publication statusPublished - Aug 1 2015



  • Citicoline
  • Glaucoma
  • PERG
  • VEP

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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