Treatment with Cyclosporine a Promotes Axonal Regeneration in Rats Submitted to Transverse Section of the Spinal Cord - II - Recovery of Function

Guido Palladini, Brunella Caronti, Guiseppe Pozzessere, Angela Teichner, Francesca R. Buttarelli, Emanuele Morselli, Elvira Valle, Giorgio Venturini, Aldo Fortuna, Francesco E. Pontieri

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Abstract

Previous reports have suggested a correlation between autoimmunity and abortive axonal regeneration in mammalian CNS. In this study we investigated the effects of immunosuppressive treatment with Cyclosporine A (CyA) (2.5 - 5 mg/kg/day) on axonal regeneration after complete spinal transection in rats. Partial recovery of function was observed 30 days after surgery in rats treated with CyA, with the presence of incomplete spontaneous locomotion and a positive contact placing reaction. Restoration of somatosensory evoked potentials and positive retrograde fluorescent tracing were also observed. CyA reduced the autoimmune reaction which targeted components of the axons. These results provide further evidence of the role played by autoimmunity in blocking regeneration of fibre tracts in mammalian CNS.

Original languageEnglish
Pages (from-to)145-153
Number of pages9
JournalJournal of Brain Research
Volume37
Issue number1
Publication statusPublished - 1996

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Keywords

  • Autoimmunity
  • CNS
  • Cyclosporine A
  • Rat
  • Regeneration

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

Cite this

Palladini, G., Caronti, B., Pozzessere, G., Teichner, A., Buttarelli, F. R., Morselli, E., Valle, E., Venturini, G., Fortuna, A., & Pontieri, F. E. (1996). Treatment with Cyclosporine a Promotes Axonal Regeneration in Rats Submitted to Transverse Section of the Spinal Cord - II - Recovery of Function. Journal of Brain Research, 37(1), 145-153.