Treatment with GnRH agonists before myomectomy and the risk of short-term myoma recurrence

L. Fedele, P. Vercellini, S. Bianchi, D. Brioschi, M. Dorta

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Twenty-four women with symptomatic multiple uterine myomas were allocated randomly to treatment with buserelin, 1200 μg/day intranasally, for 3 months followed by myomectomy (n = 8) or to immediate myomectomy (n = 16). Pre-operative treatment with buserelin reduced the mean uterine volume from 432 (SD 165) to 242 (SD 82) ml (P <0.01) but intra-operative blood loss and postoperative morbidity were not significantly less in this group. Six months after operation, pelvic examination was normal in all the patients. However, ultrasonography with transvaginal probe demonstrated the presence of myomas of <1.5 cm in five women (63%) treated pre-operatively with the analogue and in two women (13%) who underwent immediate surgery (P <0.05). Induction of a period of hypo-oestrogenism before myomectomy seems to favour short-term recurrence of uterine myomas, limiting the efficacy of surgery.

Original languageEnglish
Pages (from-to)393-396
Number of pages4
JournalBritish Journal of Obstetrics and Gynaecology
Issue number5
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Obstetrics and Gynaecology


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