Treatment with inhibitors of polyamine biosynthesis, which selectively lower intracellular spermine, does not affect the activity of alkylating agents but antagonizes the cytotoxicity of DNA topoisomerase II inhibitors

M. A. Desiderio, D. Bergamaschi, E. Mascellani, P. De Feudis, E. Erba, M. D'Incalci

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Medicine & Life Sciences