TY - JOUR
T1 - Treatment with melatonin after status epilepticus attenuates seizure activity and neuronal damage but does not prevent the disturbance in diurnal rhythms and behavioral alterations in spontaneously hypertensive rats in kainate model of temporal lobe epilepsy
AU - Petkova, Zlatina
AU - Tchekalarova, Jana
AU - Pechlivanova, Daniela
AU - Moyanova, Slavianka
AU - Kortenska, Lidia
AU - Mitreva, Rumiana
AU - Popov, Deyan
AU - Markova, Petya
AU - Lozanov, Valentin
AU - Atanasova, Dimitrina
AU - Lazarov, Nikolai
AU - Stoynev, Alexander
PY - 2014/2
Y1 - 2014/2
N2 - Melatonin is involved in the control of circadian and seasonal rhythmicity, possesses potent antioxidant activity, and exerts a neuroprotective and anticonvulsant effect. Spontaneously hypertensive rats (SHRs) are widely accepted as an experimental model of essential hypertension with hyperactivity, deficient sustained attention, and alterations in circadian autonomic profiles. The purpose of the present study was to determine whether melatonin treatment during epileptogenesis can prevent the deleterious consequences of status epilepticus (SE) in SHRs in the kainate (KA) model of temporal lobe of epilepsy (TLE). Spontaneous recurrent seizures (SRSs) were EEG- and video-recorded during and after the treatment protocol. Melatonin (10. mg/kg diluted in drinking water, 8. weeks) increased the seizure-latent period, decreased the frequency of SRSs, and attenuated the circadian rhythm of seizure activity in SHRs. However, melatonin was unable to affect the disturbed diurnal rhythms and behavioral changes associated with epilepsy, including the decreased anxiety level, depression, and impaired spatial memory. Melatonin reduced neuronal damage specifically in the CA1 area of the hippocampus and piriform cortex and decreased hippocampal serotonin (5-HT) levels both in control and epileptic SHRs. Although long-term melatonin treatment after SE shows a potential to attenuate seizure activity and neuronal loss, it is unable to restore epilepsy-associated behavioral abnormalities in SHRs.
AB - Melatonin is involved in the control of circadian and seasonal rhythmicity, possesses potent antioxidant activity, and exerts a neuroprotective and anticonvulsant effect. Spontaneously hypertensive rats (SHRs) are widely accepted as an experimental model of essential hypertension with hyperactivity, deficient sustained attention, and alterations in circadian autonomic profiles. The purpose of the present study was to determine whether melatonin treatment during epileptogenesis can prevent the deleterious consequences of status epilepticus (SE) in SHRs in the kainate (KA) model of temporal lobe of epilepsy (TLE). Spontaneous recurrent seizures (SRSs) were EEG- and video-recorded during and after the treatment protocol. Melatonin (10. mg/kg diluted in drinking water, 8. weeks) increased the seizure-latent period, decreased the frequency of SRSs, and attenuated the circadian rhythm of seizure activity in SHRs. However, melatonin was unable to affect the disturbed diurnal rhythms and behavioral changes associated with epilepsy, including the decreased anxiety level, depression, and impaired spatial memory. Melatonin reduced neuronal damage specifically in the CA1 area of the hippocampus and piriform cortex and decreased hippocampal serotonin (5-HT) levels both in control and epileptic SHRs. Although long-term melatonin treatment after SE shows a potential to attenuate seizure activity and neuronal loss, it is unable to restore epilepsy-associated behavioral abnormalities in SHRs.
KW - Diurnal rhythms
KW - Kainate model of temporal lobe epilepsy
KW - Melatonin
KW - Spontaneous hypertensive rats
UR - http://www.scopus.com/inward/record.url?scp=84892531555&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84892531555&partnerID=8YFLogxK
U2 - 10.1016/j.yebeh.2013.12.013
DO - 10.1016/j.yebeh.2013.12.013
M3 - Article
C2 - 24440891
AN - SCOPUS:84892531555
VL - 31
SP - 198
EP - 208
JO - Epilepsy and Behavior
JF - Epilepsy and Behavior
SN - 1525-5050
ER -