Treatment with rapamycin ameliorates clinical and histological signs of protracted relapsing experimental allergic encephalomyelitis in Dark Agouti rats and induces expansion of peripheral CD4+CD25+Foxp3+ regulatory T cells

Marco Donia, Katia Mangano, Alfredo Amoroso, Maria Clorinda Mazzarino, Rosa Imbesi, Paola Castrogiovanni, Marinella Coco, PierLuigi Meroni, Ferdinando Nicoletti

Research output: Contribution to journalArticle

Abstract

We have presently evaluated the effects of the immunomodulatory drug rapamycin on the course of protracted relapsing experimental allergic encephalomyelitis (PR-EAE) in Dark Agouti (DA) rats, which serves as a preclinical model of multiple sclerosis. The data show that the oral administration of rapamycin at 3 mg/kg for 28 consecutive days significantly ameliorated the course of PR-EAE in DA rats. The rats that received the medication had significantly lower clinical cumulative scores and shorter duration of the disease than did the control rats treated with the vehicle. The milder course of the disease was associated with a reduction of the histopathological signs associated to EAE: increased percentage of splenic CD4+CD25 + Foxp3+ Tregs and concomitant reduction of splenic CD8+T cells. These data suggest that rapamycin has pharmacological potential worthy of consideration in the treatment of MS patients.

Original languageEnglish
Pages (from-to)135-140
Number of pages6
JournalJournal of Autoimmunity
Volume33
Issue number2
DOIs
Publication statusPublished - Sep 2009

Keywords

  • EAE
  • Multiple sclerosis
  • Rapamycin
  • Tregs

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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